2-phenyl-4-<(1-acetyl-4,5,6,7-tetrafluoroindolyl)methylidene>-5-oxazolone

Base Information

Chemical Name:2-phenyl-4-<(1-acetyl-4,5,6,7-tetrafluoroindolyl)methylidene>-5-oxazolone
CAS No.:88752-74-3
Molecular Formula:C₂₀H₁₀F₄N₂O₃
Molecular Weight:402.305
Hs Code.:

Synonyms:2-phenyl-4-<(1-acetyl-4,5,6,7-tetrafluoroindolyl)methylidene>-5-oxazolone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-phenyl-4-<(1-acetyl-4,5,6,7-tetrafluoroindolyl)methylidene>-5-oxazolone

Chemical Property:

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Technology Process of 2-phenyl-4-<(1-acetyl-4,5,6,7-tetrafluoroindolyl)methylidene>-5-oxazolone

There total 9 articles about 2-phenyl-4-<(1-acetyl-4,5,6,7-tetrafluoroindolyl)methylidene>-5-oxazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2
Hippuric Acid

: 30683-38-6
4,5,6,7-tetrafluoro-1H-indole-3-carbaldehyde

: 108-24-7
acetic anhydride

: 88752-74-3
2-phenyl-4-<(1-acetyl-4,5,6,7-tetrafluoroindolyl)methylidene>-5-oxazolone

Guidance literature:: With sodium acetate; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)85959-6

Reference yield:

: 28834-98-2
3-methyl-4,5,6,7-tetrafluoroindole

: 88752-74-3
2-phenyl-4-<(1-acetyl-4,5,6,7-tetrafluoroindolyl)methylidene>-5-oxazolone

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / pyridine / 1.5 h / Heating

2: 86 percent / selenium dioxide / bis-(2-methoxy-ethyl) ether / 1.5 h / 160 °C

3: 91 percent / sodium acetate / tetrahydrofuran / 12 h / Heating

With pyridine; selenium(IV) oxide; sodium acetate; In tetrahydrofuran; diethylene glycol dimethyl ether;
DOI:10.1021/jo00280a014

Reference yield:

: 80841-12-9
2-(pentafluorophenyl)propanal

: 88752-74-3
2-phenyl-4-<(1-acetyl-4,5,6,7-tetrafluoroindolyl)methylidene>-5-oxazolone

Guidance literature:: Multi-step reaction with 6 steps

1: CHCl₃ / 0.5 h / Ambient temperature

2: LDA / tetrahydrofuran / Ambient temperature; 1.) -78 deg C, 2.) RT, 10 h

3: 1.) RhCl₃*3H₂O, 2.) conc. HCl / 1.) ethanol, reflux, 14 h, 2.) reflux, 20 min

4: 94 percent / pyridine / 1.5 h / Heating

5: 86 percent / selenium dioxide / bis-(2-methoxy-ethyl) ether / 1.5 h / 160 °C

6: 91 percent / sodium acetate / tetrahydrofuran / 12 h / Heating

With pyridine; hydrogenchloride; rhodium(III) chloride; selenium(IV) oxide; sodium acetate; lithium diisopropyl amide; In tetrahydrofuran; chloroform; diethylene glycol dimethyl ether;
DOI:10.1021/jo00280a014