4,5-di-tert-butyl 7-methyl (1S,3R,4S,5R)-3-[(tert-butyldiphenylsilyl)oxymethyl]-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]oct-6-ene-4,5,7-tricarboxylate

Base Information

Chemical Name:4,5-di-tert-butyl 7-methyl (1S,3R,4S,5R)-3-[(tert-butyldiphenylsilyl)oxymethyl]-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]oct-6-ene-4,5,7-tricarboxylate
CAS No.:644981-60-2
Molecular Formula:C₄₂H₆₂O₁₂Si₂
Molecular Weight:815.118
Hs Code.:

4,5-di-tert-butyl 7-methyl (1S,3R,4S,5R)-3-[(tert-butyldiphenylsilyl)oxymethyl]-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]oct-6-ene-4,5,7-tricarboxylate

Synonyms:4,5-di-tert-butyl 7-methyl (1S,3R,4S,5R)-3-[(tert-butyldiphenylsilyl)oxymethyl]-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]oct-6-ene-4,5,7-tricarboxylate

Suppliers and Price of 4,5-di-tert-butyl 7-methyl (1S,3R,4S,5R)-3-[(tert-butyldiphenylsilyl)oxymethyl]-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]oct-6-ene-4,5,7-tricarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4,5-di-tert-butyl 7-methyl (1S,3R,4S,5R)-3-[(tert-butyldiphenylsilyl)oxymethyl]-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]oct-6-ene-4,5,7-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4,5-di-tert-butyl 7-methyl (1S,3R,4S,5R)-3-[(tert-butyldiphenylsilyl)oxymethyl]-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]oct-6-ene-4,5,7-tricarboxylate

There total 14 articles about 4,5-di-tert-butyl 7-methyl (1S,3R,4S,5R)-3-[(tert-butyldiphenylsilyl)oxymethyl]-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]oct-6-ene-4,5,7-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 922-67-8
propynoic acid methyl ester

: 644981-45-3
di-tert-butyl [2R,2(1R)]-2-[2-(tert-butyldiphenylsilyl)oxy-1-[3-(methoxymethoxy)propionyl]oxyethyl]-3-diazo-2-(trimethylsilyl)oxybutanedioate

: 2-[2-(tert-butyl-diphenyl-silanyloxy)-1-(3-methoxymethoxy-propionyloxy)-ethyl]-3-hydroxy-2-trimethylsilanyloxy-succinic acid di-tert-butyl ester

: 644981-60-2
4,5-di-tert-butyl 7-methyl (1S,3R,4S,5R)-3-[(tert-butyldiphenylsilyl)oxymethyl]-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]oct-6-ene-4,5,7-tricarboxylate

Guidance literature:: dirhodium tetraacetate; In benzene; at 80 ℃; for 0.416667h;
DOI:10.1002/chem.200601212

Reference yield: 75.0%

: 922-67-8
propynoic acid methyl ester

: 644981-45-3
di-tert-butyl [2R,2(1R)]-2-[2-(tert-butyldiphenylsilyl)oxy-1-[3-(methoxymethoxy)propionyl]oxyethyl]-3-diazo-2-(trimethylsilyl)oxybutanedioate

: 644981-60-2
4,5-di-tert-butyl 7-methyl (1S,3R,4S,5R)-3-[(tert-butyldiphenylsilyl)oxymethyl]-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]oct-6-ene-4,5,7-tricarboxylate

Guidance literature:: With dirhodium tetraacetate; In benzene; for 1h; Heating;
DOI:10.1002/anie.200352629

Reference yield:

: 117384-46-0
di-tert-butyl D-tartrate

: 644981-60-2
4,5-di-tert-butyl 7-methyl (1S,3R,4S,5R)-3-[(tert-butyldiphenylsilyl)oxymethyl]-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]oct-6-ene-4,5,7-tricarboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: Bu₂SnO / toluene / 2 h / Heating

1.2: 92 percent / cesium fluoride / dimethylformamide / 10 h

2.1: LiBH₄ / tetrahydrofuran / 4 h / 20 °C

2.2: 24.5 g / LiBH₄ / tetrahydrofuran / 4 h / -78 °C

3.1: 97 percent / imidazole / CH₂Cl₂ / 0.5 h / 0 °C

4.1: 95 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h

5.1: 96 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; aq. phosphate buffer / 2 h / pH 7

6.1: 81 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 20 °C

7.1: 91 percent / methanol / 0.67 h

8.1: 97 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h

9.1: 65 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran; CH₂Cl₂ / 0.08 h / -93 °C

10.1: 94 percent / imidazole / tetrahydrofuran / 48 h

11.1: 78 percent / [Rh₂(OAc)4] bis(methanol) adduct / benzene / 0.42 h / 80 °C

With 1H-imidazole; dmap; lithium borohydride; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; di(n-butyl)tin oxide; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; dirhodium tetraacetate; In tetrahydrofuran; methanol; phosphate buffer; dichloromethane; toluene; benzene; 8.1: Dess-Martin oxidation;
DOI:10.1002/chem.200601212