N-{2-[(3S)-4-hydroxy-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

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Chemical Name:N-{2-[(3S)-4-hydroxy-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide
CAS No.:1374041-13-0
Molecular Formula:C₃₈H₄₄N₄O₈S
Molecular Weight:716.855
Hs Code.:

Synonyms:N-{2-[(3S)-4-hydroxy-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

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Chemical Property of N-{2-[(3S)-4-hydroxy-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

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Technology Process of N-{2-[(3S)-4-hydroxy-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

There total 9 articles about N-{2-[(3S)-4-hydroxy-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1374041-12-9
N-{2-[(3S)-4-{[tert-butyl(diphenyl)silyl]oxy}-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

: 1374041-13-0
N-{2-[(3S)-4-hydroxy-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: With pyridine; hydrogen fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

Reference yield:

: 23308-83-0
(2-nitrobenzyl)triphenylphosphonium bromide

: 1374041-13-0
N-{2-[(3S)-4-hydroxy-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 14 h / 20 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h

3.1: dmap; HATU / pyridine / 13 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C

4.2: 0 °C

5.1: dmap / pyridine / 13 h / 20 °C

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16.5 h / 0 - 20 °C / Darkness

7.1: pyridine; hydrogen fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

With pyridine; dmap; di-isopropyl azodicarboxylate; hydrogen fluoride; hydrogen; triphenylphosphine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;

Reference yield:

: 1374041-07-2
tert-butyl [(2S,3E)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-(2-nitrophenyl)but-3-en-2-yl]carbamate

: 1374041-13-0
N-{2-[(3S)-4-hydroxy-3-{(3-methylbutyl)[(4-nitrophenyl)sulfonyl]amino}butyl]phenyl}-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h

2.1: dmap; HATU / pyridine / 13 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C

3.2: 0 °C

4.1: dmap / pyridine / 13 h / 20 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16.5 h / 0 - 20 °C / Darkness

6.1: pyridine; hydrogen fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

With pyridine; dmap; di-isopropyl azodicarboxylate; hydrogen fluoride; hydrogen; triphenylphosphine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; dichloromethane; ethyl acetate;