N-cyclopropyl-4-{6-[(3-fluoro-4-methoxyphenyl)(hydroxy)methyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-4-{6-[(3-fluoro-4-methoxyphenyl)(hydroxy)methyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide
CAS No.:1401450-90-5
Molecular Formula:C₂₉H₂₈F₄N₄O₃
Molecular Weight:556.56
Hs Code.:

Synonyms:N-cyclopropyl-4-{6-[(3-fluoro-4-methoxyphenyl)(hydroxy)methyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

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Chemical Property of N-cyclopropyl-4-{6-[(3-fluoro-4-methoxyphenyl)(hydroxy)methyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

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Technology Process of N-cyclopropyl-4-{6-[(3-fluoro-4-methoxyphenyl)(hydroxy)methyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

There total 9 articles about N-cyclopropyl-4-{6-[(3-fluoro-4-methoxyphenyl)(hydroxy)methyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1401450-86-9
N-cyclopropyl-4-{6-(3-fluoro-4-methoxybenzoyl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

: 1401450-90-5
N-cyclopropyl-4-{6-[(3-fluoro-4-methoxyphenyl)(hydroxy)methyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Guidance literature:: N-cyclopropyl-4-{6-(3-fluoro-4-methoxybenzoyl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide; With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 23 ℃; for 1h;

With ammonium chloride; In ethyl acetate;

Reference yield:

: 1121586-23-9
5-bromobenzene-1,2,3-triamine

: 1401450-90-5
N-cyclopropyl-4-{6-[(3-fluoro-4-methoxyphenyl)(hydroxy)methyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / 20 °C / Reflux

1.2: pH 8

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 23 °C

2.2: 3 °C

3.1: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 60 h / 23 °C

4.1: N-ethyl-N,N-diisopropylamine; palladium diacetate; catacxium A / toluene / 100 °C / 10501.1 Torr

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 23 °C

6.1: dmap; HATU / N,N-dimethyl-formamide / 23 °C

7.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 1 h / 23 °C

With pyridine; pyridine N-oxide; hydrogenchloride; methanol; dmap; sodium tetrahydroborate; water; copper diacetate; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; catacxium A; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 62554-90-9
4-bromo-2,6-dinitroaniline

: 1401450-90-5
N-cyclopropyl-4-{6-[(3-fluoro-4-methoxyphenyl)(hydroxy)methyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; tin(II) chloride dihdyrate / water / -20 - 20 °C

1.2: pH 10

2.1: hydrogenchloride / 20 °C / Reflux

2.2: pH 8

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 23 °C

3.2: 3 °C

4.1: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 60 h / 23 °C

5.1: N-ethyl-N,N-diisopropylamine; palladium diacetate; catacxium A / toluene / 100 °C / 10501.1 Torr

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 23 °C

7.1: dmap; HATU / N,N-dimethyl-formamide / 23 °C

8.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 1 h / 23 °C

With pyridine; pyridine N-oxide; hydrogenchloride; methanol; dmap; sodium tetrahydroborate; tin(II) chloride dihdyrate; water; copper diacetate; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; catacxium A; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;