2-(2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)-N,N-dimethylethanamide

Base Information

• Chemical Name: 2-(2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)-N,N-dimethylethanamide
• CAS No.: 82626-46-8
• Molecular Formula: C₁₈H₁₈FN₃O
• Molecular Weight: 311.359
• Mol file: 82626-46-8.mol

Synonyms:2-(2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)-N,N-dimethylethanamide

Chemical Property of 2-(2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)-N,N-dimethylethanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)-N,N-dimethylethanamide

There total 4 articles about 2-(2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)-N,N-dimethylethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(2-(4-fluorophenyl)-6-methylimidazo[1,2-α]pyridin-3-yl)-2-hydroxy-N,N-dimethylacetamide → 2-(2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)-N,N-dimethylethanamide (82626-46-8)

Guidance literature:

With phosphorus tribromide; In 1,4-dioxane; for 0.75h; Solvent; Irradiation; Heating;

DOI:10.3390/molecules25143161

Reference yield:

2-(4-fluorophenyl)-6-methylH-imidazo[1,2-a]pyridine → 2-(2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)-N,N-dimethylethanamide (82626-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / 40 °C

1.2: 2 h / 20 °C / pH Ca_. 10

2.1: phosphorus tribromide / 1,2-dichloro-ethane

With phosphorus tribromide; acetic acid; In 1,2-dichloro-ethane;

DOI:10.1016/j.ejmech.2016.08.059

Reference yield:

2-bromo-4'-fluoroacetophenone (403-29-2) → 2-(2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)-N,N-dimethylethanamide (82626-46-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / toluene / 12 h / Reflux

2.1: acetic acid / 40 °C

2.2: 2 h / 20 °C / pH Ca_. 10

3.1: phosphorus tribromide / 1,2-dichloro-ethane

With phosphorus tribromide; sodium hydrogencarbonate; acetic acid; In 1,2-dichloro-ethane; toluene;

DOI:10.1016/j.ejmech.2016.08.059

upstream raw materials:

(5-methyl-pyridin-2-yl)amine

2-bromo-4'-fluoroacetophenone