N-(2-bromo-5-trifluoromethyl-phenyl)-N-methyl-2-fluoro-2-phenylacetamide

Base Information

Chemical Name:N-(2-bromo-5-trifluoromethyl-phenyl)-N-methyl-2-fluoro-2-phenylacetamide
CAS No.:1379665-20-9
Molecular Formula:C₁₆H₁₂BrF₄NO
Molecular Weight:390.175
Hs Code.:

Synonyms:N-(2-bromo-5-trifluoromethyl-phenyl)-N-methyl-2-fluoro-2-phenylacetamide

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Chemical Property of N-(2-bromo-5-trifluoromethyl-phenyl)-N-methyl-2-fluoro-2-phenylacetamide

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Technology Process of N-(2-bromo-5-trifluoromethyl-phenyl)-N-methyl-2-fluoro-2-phenylacetamide

There total 3 articles about N-(2-bromo-5-trifluoromethyl-phenyl)-N-methyl-2-fluoro-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₀BrF₄NO

: 74-88-4
methyl iodide

: 1379665-20-9
N-(2-bromo-5-trifluoromethyl-phenyl)-N-methyl-2-fluoro-2-phenylacetamide

Guidance literature:: C₁₅H₁₀BrF₄NO; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201200206

Reference yield:

: 1578-63-8
d'acide 2-fluoro-2-phenyl acetique

: 1379665-20-9
N-(2-bromo-5-trifluoromethyl-phenyl)-N-methyl-2-fluoro-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With dmap; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1002/anie.201200206

Reference yield:

: 58458-10-9
bromo-3-(trifluoromethyl)-aniline

: 1379665-20-9
N-(2-bromo-5-trifluoromethyl-phenyl)-N-methyl-2-fluoro-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With dmap; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1002/anie.201200206