(R)-1-Isopropyl-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Base Information

Chemical Name:(R)-1-Isopropyl-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
CAS No.:1042980-75-5
Molecular Formula:C₃₁H₄₀N₂O₂
Molecular Weight:472.671
Hs Code.:

Synonyms:(R)-1-Isopropyl-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

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Chemical Property of (R)-1-Isopropyl-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

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Technology Process of (R)-1-Isopropyl-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

There total 4 articles about (R)-1-Isopropyl-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 65601-08-3
1-isopropyl-4,9-dihydro-3H-pyrido[3,4-b]indole

: 126378-43-6
(1R,2S,5R)-(-)-8-phenylmenthyl chloroformate

: 1042980-75-5
(R)-1-Isopropyl-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: 1-isopropyl-4,9-dihydro-3H-pyrido[3,4-b]indole; (1R,2S,5R)-(-)-8-phenylmenthyl chloroformate;

With triethylsilane; triethylamine; palladium dichloride; In dichloromethane; at -78 ℃; Further stages.;
DOI:10.1016/j.tetlet.2008.04.130

Reference yield:

: 65601-08-3
1-isopropyl-4,9-dihydro-3H-pyrido[3,4-b]indole

: 126378-43-6
(1R,2S,5R)-(-)-8-phenylmenthyl chloroformate

: (S)-1-Isopropyl-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

: 1042980-75-5
(R)-1-Isopropyl-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: 1-isopropyl-4,9-dihydro-3H-pyrido[3,4-b]indole; (1R,2S,5R)-(-)-8-phenylmenthyl chloroformate; In dichloromethane; at 20 ℃; for 0.5h;

With triethylsilane; triethylamine; palladium dichloride; In dichloromethane; at 60 ℃; for 0.15h; optical yield given as %de; diastereoselective reaction; Microwave irradiation;
DOI:10.1016/j.tetlet.2009.09.181

Reference yield:

: 78-84-2
isobutyraldehyde

: [2-(1H-Indol-3-yl)-ethyl]-carbamic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

: (S)-1-Isopropyl-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

: 1042980-75-5
(R)-1-Isopropyl-1,3,4,9-tetrahydro-β-carboline-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: With chloro-trimethyl-silane; In dichloromethane; at -30 ℃; for 24h; Title compound not separated from byproducts;
DOI:10.1016/S0957-4166(02)00793-0