2-(4-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-phenoxy}-butyl)-isoindole-1,3-dione

Base Information

Chemical Name:2-(4-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-phenoxy}-butyl)-isoindole-1,3-dione
CAS No.:819066-97-2
Molecular Formula:C₄₄H₄₃N₇O₃
Molecular Weight:717.871
Hs Code.:

Synonyms:2-(4-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-phenoxy}-butyl)-isoindole-1,3-dione

Suppliers and Price of 2-(4-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-phenoxy}-butyl)-isoindole-1,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-phenoxy}-butyl)-isoindole-1,3-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(4-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-phenoxy}-butyl)-isoindole-1,3-dione

There total 8 articles about 2-(4-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-phenoxy}-butyl)-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1539-42-0
bis[(2-pyridyl)methyl]amine

: 819066-96-1
2-(4-(3,5-bis(bromomethyl)phenoxy)butyl)isoindoline-1,3-dione

: 819066-97-2
2-(4-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-phenoxy}-butyl)-isoindole-1,3-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.08.052

Reference yield:

: 618-83-7
5-Hydroxyisophthalic acid

: 819066-97-2
2-(4-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-phenoxy}-butyl)-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂SO₄ / Heating

2: 96 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

3: 90 percent / K₂CO₃ / acetonitrile / 24 h / Heating

4: 89 percent / CBr₄; Ph₃P / CH₂Cl₂ / 20 °C

5: 91 percent / K₂CO₃ / dimethylformamide

With lithium aluminium tetrahydride; carbon tetrabromide; sulfuric acid; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2004.08.052

Reference yield:

: 153707-56-3
3,5-bis(hydroxymethyl)phenol

: 819066-97-2
2-(4-{3,5-bis-[(bis-pyridin-2-ylmethyl-amino)-methyl]-phenoxy}-butyl)-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / K₂CO₃ / acetonitrile / 24 h / Heating

2: 89 percent / CBr₄; Ph₃P / CH₂Cl₂ / 20 °C

3: 91 percent / K₂CO₃ / dimethylformamide

With carbon tetrabromide; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2004.08.052