C₁₂H₁₅NO₂

Base Information

• Chemical Name: C₁₂H₁₅NO₂
• CAS No.: 334651-13-7
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 334651-13-7.mol

Synonyms:C₁₂H₁₅NO₂

Chemical Property of C₁₂H₁₅NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₅NO₂

There total 2 articles about C₁₂H₁₅NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycine isopropyl ester (13048-66-3) + benzaldehyde (100-52-7) → C12H15NO2 (334651-13-7)

Guidance literature:

glycine isopropyl ester; With magnesium sulfate; triethylamine; In dichloromethane; at 20 ℃; for 1h;

benzaldehyde; In dichloromethane; at 20 ℃;

DOI:10.1039/c4cc06632d

Reference yield:

glycine isopropyl ester hydrochloride (14019-62-6) + benzaldehyde (100-52-7) → C12H15NO2 (334651-13-7)

Guidance literature:

glycine isopropyl ester hydrochloride; With magnesium sulfate; triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

benzaldehyde; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jacs.8b10939

Reference yield: 96.0%

C12H15NO2 (334651-13-7) + (E)-ethyl 3-(6-chloro-9H-purin-9-yl)acrylate → 2-isopropyl 4-ethyl (2R,3S,4R,5S)-3-(6-chloro-9H-purin-9-yl)-5-phenylpyrrolidine-2,4-dicarboxylate

Guidance literature:

With tetrakis(acetonitrile)copper(I) perchlorate; (R,R,R)-[2-(4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl)ferrocenyl]diphenylphosphine; potassium carbonate; In dichloromethane; at -25 ℃; for 16h; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c4cc06632d

upstream raw materials:

glycine isopropyl ester

benzaldehyde

glycine isopropyl ester hydrochloride

Downstream raw materials:

4-tert-butyl 2-isopropyl (2S,4S,5R)-5-phenyl-2,4-pyrrolidinedicarboxylate

4-tert-butyl 2-isopropyl (2R,4R,5S)-5-phenyl-2,4-pyrrolidinedicarboxylate

triisopropyl 5-phenyl-1H-1,2,4-triazole-1,2,3(5H)-tricarboxylate

isopropyl (1S,3R,3aS,6aR)-5-methyl-3-phenyl-4,6-dioxooctahydropyrrolo[3,4-c]pyrrole-1-carboxylate