13048-66-3

Basic information

• Product Name: Glycine 1-methylethyl ester
• Synonyms: Glycine 1-methylethyl ester;YLGOWOYJZYKTDO-UHFFFAOYSA-N
• CAS NO: 13048-66-3
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.15
• Mol File: 13048-66-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 127.78 °C at 760 mmHg
• Flash Point: 3.533 °C
• Appearance: White crystalline powder
• Density: 0.988 g/cm³
• Vapor Pressure: 10.957mmHg at 25°C
• Refractive Index: 1.427
• PKA: 7.65±0.29(Predicted)
• CAS DataBase Reference: Glycine 1-methylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine 1-methylethyl ester(13048-66-3)
• EPA Substance Registry System: Glycine 1-methylethyl ester(13048-66-3)

Safety Data

• Hazardous Substances Data: 13048-66-3(Hazardous Substances Data)

Usage

General Description

Glycine 1-methylethyl ester, also known as sarcosine methyl ester, is a chemical compound consisting of glycine with a methyl group and an ethyl group attached to the nitrogen atom. It is commonly used as a precursor in organic synthesis and in the production of pharmaceuticals and agrochemicals. Glycine 1-methylethyl ester has been studied for its potential as a therapeutic agent, particularly in the treatment of schizophrenia and depression. It has also been investigated for its role in enhancing cognitive function and improving symptoms of certain neurological disorders. Additionally, it has been explored for its potential use in the field of cosmetic and personal care products.

InChI:InChI=1/C5H11NO2/c1-4(2)8-5(7)3-6/h4H,3,6H2,1-2H3

Upstream product

• 14019-62-6 glycine isopropyl ester hydrochloride 
• 197579-95-6 N-Boc-glycine isopropylester 
• 67-63-0 isopropyl alcohol 
• 56-40-6 glycine 

Downstream Products

• 106-57-0 Glycine anhydride 
• 118209-03-3 Z-Phe-Gly-D-Ala-OMe 
• 118209-05-5 Z-Phe-Gly-D-Phe-OMe 
• 119244-11-0 N-(diphenylmethylidene)glycine isopropyl ester 
• 335155-02-7 1-(4-[N-(2-iso-propyloxy-2-oxoethylcarbamoyl)aminomethyl]-3-methylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 334651-13-7 C₁₂H₁₅NO₂ 
• 1571134-22-9 C₂₇H₂₅F₃N₄O₄ 
• 105-48-6 isopropyl chloroacetate 
• 63471-47-6 N-[O⁴,O⁶-((R)-benzylidene)-D-fructose-1-yl]-glycine-isopropyl ester 
• 138892-11-2 isopropyl (S)-2-[(diphenylmethylidene)amino]-3-phenylpropanoate 
• 118209-07-7 Z-Leu-Gly-D-Leu-OMe 
• 118209-08-8 Z-Val-Gly-D-Leu-OMe 
• 118209-09-9 Z-Ala-Gly-D-Leu-OMe 
• 118209-04-4 Z-Phe-Gly-D-Val-OMe 

Relevant articles and documents

Reactions of coordinated ligands. XX. Cobalt (3)-promoted hydrolysis of glycine t-butyl ester.

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Stable carbon isotope analysis of amino acid enantiomers by conventional isotope ratio mass spectrometry and combined gas chromatography/isotope ratio mass spectrometry

The application of a combined gas chromatography/isotope ratio mass spectrometry (GC/IRMS) method for stable carbon isotope analysis of amino acid enantiomers is presented. This method eliminates the numerous preparative steps integral to the isolation of amino acids and amino acid enantiomers from protein hydrolyzates that precede δ13C analysis by conventional isotope ratio mass spectrometry. Unlike hydrocarbons, amino acids require derivatization prior to GC/ IRMS analysis. Replicate δ13C analyses of trifluoroacetyl (TFA) isopropyl ester derivatives of 22 amino acids by IRMS revealed that the derivatization process is reproducible, with an average error (1 standard deviation) of 0.10‰ ± 0.09 ‰. The average analytical error for analysis of amino acid derivatives by GC/IRMS was 0.26‰ ± 0.09‰. In general, absolute differences between IRMS and GC/IRMS analyses were less than 0.5‰. The derivatization process introduces a distinct, reproducible isotopic fractionation that is constant for each amino acid type. The observed fractionations preclude direct calculation of underivatized amino acid δ13C values from their respective TFA isopropyl ester δ13C compositions through mass balance relationships. Derivatization of amino acid standards of known stable carbon isotope compositions in conjunction with natural samples, however, permits computation of the original, underivatized amino acid δ13C values through use of an empirical correction for the carbon introduced during the derivatization process.

A cation-directed two-component cascade approach to enantioenriched pyrroloindolines

A cascade approach to complex pyrroloindolines bearing all-carbon quaternary stereocentres has been developed. This two-component process uses a chiral ammonium salt to control diastereo- and enantioselectivity in the addition of isocyanides to functionalized alkenes to afford pyrroloindolines with up to three stereocentres. A mechanistic proposal involving intramolecular hydrogen bond activation of the isocyanide is described.

One-pot conversion of t-butyl carbamates to amides with acyl halide-methanol mixtures

Acyl halide-methanol mixtures are efficient reagents for the one-pot transformation of t-butyl carbamates into amides. This transformation can be carried out in the presence of a benzyloxycarbonyl group.