4-{3-(bromomethyl)benzyl}-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:4-{3-(bromomethyl)benzyl}-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:258885-48-2
Molecular Formula:C₁₂H₁₄BrN₃O₂
Molecular Weight:312.166
Hs Code.:

Synonyms:4-{3-(bromomethyl)benzyl}-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 4-{3-(bromomethyl)benzyl}-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

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Technology Process of 4-{3-(bromomethyl)benzyl}-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 5 articles about 4-{3-(bromomethyl)benzyl}-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82072-23-9
3-(bromomethyl)benzaldehyde

: 258885-48-2
4-{3-(bromomethyl)benzyl}-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / water; acetonitrile

2: water; N,N-dimethyl-formamide

3: sodium borohydrid; ammonium chloride / tetrahydrofuran; methanol

4: sodium hydrogencarbonate / (2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; tert-butyl methyl ether; water

With sodium borohydrid; ammonium chloride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; tert-butyl methyl ether; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 258885-50-6
4-{3-(hydroxymethyl)benzyl}-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

: 7789-60-8
phosphorus tribromide

: 258885-48-2
4-{3-(bromomethyl)benzyl}-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: With sodium hydrogencarbonate; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; tert-butyl methyl ether; water;

Reference yield:

: 258885-51-7
4-(3-formylbenzyl)-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

: 258885-48-2
4-{3-(bromomethyl)benzyl}-5-methoxy-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium borohydrid; ammonium chloride / tetrahydrofuran; methanol

2: sodium hydrogencarbonate / (2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; tert-butyl methyl ether; water

With sodium borohydrid; ammonium chloride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; tert-butyl methyl ether; water;