C₂₁H₁₆ClF₄N₃O₃

Base Information

• Chemical Name: C₂₁H₁₆ClF₄N₃O₃
• CAS No.: 1402585-17-4
• Molecular Formula: C₂₁H₁₆ClF₄N₃O₃
• Molecular Weight: 469.823
• Mol file: 1402585-17-4.mol

Synonyms:C₂₁H₁₆ClF₄N₃O₃

Chemical Property of C₂₁H₁₆ClF₄N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₆ClF₄N₃O₃

There total 14 articles about C₂₁H₁₆ClF₄N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + C20H14ClF4N3O3 (1402586-71-3) → C21H16ClF4N3O3 (1402585-17-4)

Guidance literature:

With thionyl chloride; at 0 - 40 ℃; for 4.5h; Cooling with ice;

Reference yield:

(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine (1254713-79-5) → C21H16ClF4N3O3 (1402585-17-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 23 °C / Cooling with ice

2: ethanol; sodium hydroxide / 4 h / 80 °C

3: thionyl chloride / 4.5 h / 0 - 40 °C / Cooling with ice

With thionyl chloride; ethanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In dichloromethane;

Reference yield:

C14H14ClN3 (1402586-55-3) → C21H16ClF4N3O3 (1402585-17-4)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 23 °C / Cooling with ice

3: ethanol; sodium hydroxide / 4 h / 80 °C

4: thionyl chloride / 4.5 h / 0 - 40 °C / Cooling with ice

With thionyl chloride; ethanol; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane;

upstream raw materials:

methanol

C₂₀H₁₄ClF₄N₃O₃

C₁₄H₁₄ClN₃

(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

Downstream raw materials:

N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(hydroxymethyl)phenyl]acetamide