Technology Process of N-(3-hydroxypropyl)-2,2-diphenylacetamide
There total 4 articles about N-(3-hydroxypropyl)-2,2-diphenylacetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 17h;
Inert atmosphere;
DOI:10.1016/j.bmc.2013.07.004
- Guidance literature:
-
With
tetrabutyl ammonium fluoride; acetic acid;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1002/anie.201708665
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane; dibutyl ether / 0 - 20 °C / Inert atmosphere
3: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere
With
tetrabutyl ammonium fluoride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; dibutyl ether;
DOI:10.1002/anie.201708665
