N-methyliminodiacetyl (1-(4-fluorophenyl)-2-oxoethyl)boronate

Base Information

• Chemical Name: N-methyliminodiacetyl (1-(4-fluorophenyl)-2-oxoethyl)boronate
• CAS No.: 1329422-57-2
• Molecular Formula: C₁₃H₁₃BFNO₅
• Molecular Weight: 293.059
• Mol file: 1329422-57-2.mol

Synonyms:N-methyliminodiacetyl (1-(4-fluorophenyl)-2-oxoethyl)boronate

Chemical Property of N-methyliminodiacetyl (1-(4-fluorophenyl)-2-oxoethyl)boronate

Chemical Property:

• Melting Point: 168-173°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Fluorophenyl-α-MIDA-boryl aldehyde 95% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyliminodiacetyl (1-(4-fluorophenyl)-2-oxoethyl)boronate

There total 4 articles about N-methyliminodiacetyl (1-(4-fluorophenyl)-2-oxoethyl)boronate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-methyliminodiacetyl (trans-3-(4-fluorophenyl)oxiran-2-yl)boronate → N-methyliminodiacetyl (1-(4-fluorophenyl)-2-oxoethyl)boronate (1329422-57-2)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -30 - 0 ℃; for 0.5h; regioselective reaction;

DOI:10.1021/ja205910d

Reference yield:

C13H13BFNO5 → N-methyliminodiacetyl (1-(4-fluorophenyl)-2-oxoethyl)boronate (1329422-57-2)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -40 ℃; for 0.833333h; Cooling with ice;

DOI:10.1021/acs.orglett.5b02861

Reference yield:

C13H13BFNO4 (1312815-41-0,1330092-65-3) → N-methyliminodiacetyl (1-(4-fluorophenyl)-2-oxoethyl)boronate (1329422-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 20 °C

2: boron trifluoride diethyl etherate / dichloromethane / 0.83 h / -40 °C / Cooling with ice

With boron trifluoride diethyl etherate; In dichloromethane; acetone;

DOI:10.1021/acs.orglett.5b02861

upstream raw materials:

C₁₃H₁₃BFNO₄

Downstream raw materials:

2-(MIDA boryl)-2-(4-fluorophenyl)acetic acid

(MIDA boryl)(4-fluorophenyl)methyl isocyanate