2-(MIDA boryl)-2-(4-fluorophenyl)acetic acid

Base Information

• Chemical Name: 2-(MIDA boryl)-2-(4-fluorophenyl)acetic acid
• CAS No.: 1380504-04-0
• Molecular Formula: C₁₃H₁₃BFNO₆
• Molecular Weight: 309.059
• Mol file: 1380504-04-0.mol

Synonyms:2-(MIDA boryl)-2-(4-fluorophenyl)acetic acid

Chemical Property of 2-(MIDA boryl)-2-(4-fluorophenyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(MIDA boryl)-2-(4-fluorophenyl)acetic acid

There total 1 articles about 2-(MIDA boryl)-2-(4-fluorophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-methyliminodiacetyl (1-(4-fluorophenyl)-2-oxoethyl)boronate (1329422-57-2) → 2-(MIDA boryl)-2-(4-fluorophenyl)acetic acid (1380504-04-0)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; In water; tert-butyl alcohol; cyclohexene; at 20 ℃;

DOI:10.1021/ja304173d

Reference yield: 62.0%

2-(MIDA boryl)-2-(4-fluorophenyl)acetic acid (1380504-04-0) → (MIDA boryl)(4-fluorophenyl)methyl isocyanate (1380504-16-4)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In acetonitrile; at 50 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ja304173d

Reference yield: 62.0%

diphenyl phosphoryl azide (26386-88-9) + 2-(MIDA boryl)-2-(4-fluorophenyl)acetic acid (1380504-04-0) → (MIDA boryl)(4-fluorophenyl)methyl isocyanate (1380504-16-4)

Guidance literature:

With triethylamine; In acetonitrile; boryl acid, azide-compound, N(C2H5)3, anhyd. CH3CN, 50°C, 1 h; silica gel chromy.;

DOI:10.1021/ja304173d

upstream raw materials:

N-methyliminodiacetyl (1-(4-fluorophenyl)-2-oxoethyl)boronate

Downstream raw materials:

(MIDA boryl)(4-fluorophenyl)methyl isocyanate

MIDA ((4-fluorophenyl)oxomethyl)boronate

MIDA ((4-fluorophenyl)(hydroxy)methyl)boronate