6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-benzyl-1H-1,2,3-triazol-4-yl)pyridine-2-carboxylic acid

Base Information

Chemical Name:6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-benzyl-1H-1,2,3-triazol-4-yl)pyridine-2-carboxylic acid
CAS No.:1430749-60-2
Molecular Formula:C₃₂H₂₅N₇O₃S
Molecular Weight:587.662
Hs Code.:

Synonyms:6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-benzyl-1H-1,2,3-triazol-4-yl)pyridine-2-carboxylic acid

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Chemical Property of 6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-benzyl-1H-1,2,3-triazol-4-yl)pyridine-2-carboxylic acid

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Technology Process of 6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-benzyl-1H-1,2,3-triazol-4-yl)pyridine-2-carboxylic acid

There total 10 articles about 6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-benzyl-1H-1,2,3-triazol-4-yl)pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 878798-87-9
2-(tert-butoxycarbonyl)-1,2,3 ,4-tetrahydroisoquinoline-8-carboxylic acid

: 1430749-60-2
6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-benzyl-1H-1,2,3-triazol-4-yl)pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

2: hydrogenchloride / dichloromethane; diethyl ether / 20 °C

3: caesium carbonate / N,N-dimethyl acetamide / 12 h / 120 °C

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 36 h / 85 °C / Inert atmosphere; Sealed tube

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6: sodium azide; sodium L-ascorbate; copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide; water / 70 °C

7: trifluoroacetic acid / dichloromethane / 2 h

With hydrogenchloride; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; caesium carbonate; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;

Reference yield:

: 929000-66-8
3-bromo-6-chloropyridine-2-carboxylic acid

: 1430749-60-2
6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-benzyl-1H-1,2,3-triazol-4-yl)pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: p-toluenesulfonyl chloride; pyridine / tert-butyl alcohol / 12 h / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl acetamide / 12 h / 120 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 36 h / 85 °C / Inert atmosphere; Sealed tube

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5: sodium azide; sodium L-ascorbate; copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide; water / 70 °C

6: trifluoroacetic acid / dichloromethane / 2 h

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; caesium carbonate; sodium L-ascorbate; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; tert-butyl alcohol;