3-Bromo-6-chloro-2-pyridinecarboxylic acid

Base Information

• Chemical Name: 3-Bromo-6-chloro-2-pyridinecarboxylic acid
• CAS No.: 929000-66-8
• Molecular Formula: C6H3BrClNO2
• Molecular Weight: 236.452
• Hs Code.: 2933399090
• Mol file: 929000-66-8.mol

Synonyms:3-Bromo-6-chloropyridine-2-carboxylic acid

Chemical Property of 3-Bromo-6-chloro-2-pyridinecarboxylic acid

Chemical Property:

• Vapor Pressure: 3.7E-05mmHg at 25°C
• Refractive Index: 1.629
• Boiling Point: 338.9 °C at 760 mmHg
• PKA: 1.92±0.10(Predicted)
• Flash Point: 158.8 °C
• PSA: 50.19000
• Density: 1.917 g/cm³
• LogP: 2.19570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

3-Bromo-6-chloropicolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-6-chloropicolinic Acid is a useful compound used in synthesis of antagonists of BCL-xL proteins which is used in the treatment of cancer, immune and autoimmune diseases.

Technology Process of 3-Bromo-6-chloro-2-pyridinecarboxylic acid

There total 1 articles about 3-Bromo-6-chloro-2-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-bromo-6-chloropyridine-2-carbonitrile (1053659-39-4) → 3-bromo-6-chloropyridine-2-carboxylic acid (929000-66-8)

Guidance literature:

With sulfuric acid; at 170 ℃; for 3h;

Reference yield: 100.0%

3-bromo-6-chloropyridine-2-carboxylic acid (929000-66-8) + tert-butyl alcohol (75-65-0) → tert-butyl 3-bromo-6-chloropicolinate (1235036-15-3)

Guidance literature:

With pyridine; p-toluenesulfonyl chloride; at 0 - 12 ℃; for 12h;

Reference yield: 100.0%

methanol (67-56-1) + 3-bromo-6-chloropyridine-2-carboxylic acid (929000-66-8) → methyl 3-bromo-6-chloro-pyridine-2-carboxylate (1214328-96-7)

Guidance literature:

With sulfuric acid; for 28h; Reflux;

upstream raw materials:

3-bromo-6-chloropyridine-2-carbonitrile

Downstream raw materials:

tert-butyl 3-bromo-6-chloropicolinate

methyl 3-bromo-6-chloro-pyridine-2-carboxylate

3-bromo-6-chloro-2-(methoxycarbonyl)pyridine 1-oxide

4-azido-3-bromo-6-chloro-pyridine-2-carboxylic acid methyl ester

Refernces