tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)picolinate

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Chemical Name:tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)picolinate
CAS No.:1430752-69-4
Molecular Formula:C₃₆H₃₃N₇O₃S
Molecular Weight:643.769
Hs Code.:

Synonyms:tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)picolinate

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Chemical Property of tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)picolinate

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Technology Process of tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)picolinate

There total 9 articles about tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 878798-87-9
2-(tert-butoxycarbonyl)-1,2,3 ,4-tetrahydroisoquinoline-8-carboxylic acid

: 1430752-69-4
tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)picolinate

Guidance literature:: Multi-step reaction with 6 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

2: hydrogenchloride / dichloromethane; diethyl ether / 20 °C

3: caesium carbonate / N,N-dimethyl acetamide / 12 h / 120 °C

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 36 h / 85 °C / Inert atmosphere; Sealed tube

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6: sodium azide; sodium L-ascorbate; copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide; water / 70 °C

With hydrogenchloride; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; caesium carbonate; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;

Reference yield:

: 929000-66-8
3-bromo-6-chloropyridine-2-carboxylic acid

: 1430752-69-4
tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)picolinate

Guidance literature:: Multi-step reaction with 5 steps

1: p-toluenesulfonyl chloride; pyridine / tert-butyl alcohol / 12 h / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl acetamide / 12 h / 120 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 36 h / 85 °C / Inert atmosphere; Sealed tube

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5: sodium azide; sodium L-ascorbate; copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide; water / 70 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; caesium carbonate; sodium L-ascorbate; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; tert-butyl alcohol;