8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-hydroxyphenyl)-1'-azetidinyl]aminoquinoline

Base Information

Chemical Name:8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-hydroxyphenyl)-1'-azetidinyl]aminoquinoline
CAS No.:1321948-28-0
Molecular Formula:C₂₀H₁₈ClN₃O₃
Molecular Weight:383.834
Hs Code.:

Synonyms:8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-hydroxyphenyl)-1'-azetidinyl]aminoquinoline

Suppliers and Price of 8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-hydroxyphenyl)-1'-azetidinyl]aminoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-hydroxyphenyl)-1'-azetidinyl]aminoquinoline

Chemical Property:

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Technology Process of 8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-hydroxyphenyl)-1'-azetidinyl]aminoquinoline

There total 4 articles about 8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-hydroxyphenyl)-1'-azetidinyl]aminoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 878386-84-6
8-methoxy-4-methyl-2-(o-hydroxyphenylidenyl-iminoamino)quinoline

: 79-04-9
chloroacetyl chloride

: 1321948-28-0
8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-hydroxyphenyl)-1'-azetidinyl]aminoquinoline

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 5 ℃; Reflux;
DOI:10.5012/bkcs.2010.31.12.3605

Reference yield:

: 30198-01-7
8-methoxy-4-methyl-quinolin-2-ol

: 1321948-28-0
8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-hydroxyphenyl)-1'-azetidinyl]aminoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 0.5 h / 80 - 85 °C

2: hydrazine hydrate / ethanol / 6 h / Reflux

3: acetic acid / methanol / Reflux

4: triethylamine / N,N-dimethyl-formamide / 0 - 5 °C / Reflux

With hydrazine hydrate; acetic acid; triethylamine; trichlorophosphate; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.5012/bkcs.2010.31.12.3605

Reference yield:

: 30198-01-7,89445-80-7
2-chloro-8-methoxy-4-methylquinoline

: 1321948-28-0
8-methoxy-4-methyl-2-[3'-chloro-2'-oxo-4'-(o-hydroxyphenyl)-1'-azetidinyl]aminoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 6 h / Reflux

2: acetic acid / methanol / Reflux

3: triethylamine / N,N-dimethyl-formamide / 0 - 5 °C / Reflux

With hydrazine hydrate; acetic acid; triethylamine; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.5012/bkcs.2010.31.12.3605