Technology Process of (+/-)-19-(4-fluorophenyl)-17-methyl-7-(3-methyl-1H-1,2,4-triazol-1-yl)-11,12,13,14,16,17,18,19-octahydro-10H-15,2-(azeno)-8,4-(metheno)pyrido[3,4-h][1,6,10,12]oxatriazacycloheptadecine trifluoroacetate
There total 10 articles about (+/-)-19-(4-fluorophenyl)-17-methyl-7-(3-methyl-1H-1,2,4-triazol-1-yl)-11,12,13,14,16,17,18,19-octahydro-10H-15,2-(azeno)-8,4-(metheno)pyrido[3,4-h][1,6,10,12]oxatriazacycloheptadecine trifluoroacetate which
guide to synthetic route it.
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synthetic route:
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![(+/-)-19-(4-fluorophenyl)-17-methyl-7-(3-methyl-1H-1,2,4-triazol-1-yl)-11,12,13,14,16,17,18,19-octahydro-10H-15,2-(azeno)-8,4-(metheno)pyrido[3,4-h][1,6,10,12]oxatriazacycloheptadecine trifluoroacetate](/Databaselist/images/loading.webp)
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1356008-84-8
(+/-)-19-(4-fluorophenyl)-17-methyl-7-(3-methyl-1H-1,2,4-triazol-1-yl)-11,12,13,14,16,17,18,19-octahydro-10H-15,2-(azeno)-8,4-(metheno)pyrido[3,4-h][1,6,10,12]oxatriazacycloheptadecine trifluoroacetate
- Guidance literature:
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With
sulfuric acid;
In
1-methyl-pyrrolidin-2-one;
at 90 ℃;
for 24h;
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1356008-84-8
(+/-)-19-(4-fluorophenyl)-17-methyl-7-(3-methyl-1H-1,2,4-triazol-1-yl)-11,12,13,14,16,17,18,19-octahydro-10H-15,2-(azeno)-8,4-(metheno)pyrido[3,4-h][1,6,10,12]oxatriazacycloheptadecine trifluoroacetate
- Guidance literature:
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Multi-step reaction with 10 steps
1.1: sodium hydride / tetrahydrofuran / 0.25 h / -10 °C
1.2: 40 °C
2.1: hydrogen; sulfuric acid / palladium 10% on activated carbon / acetic acid / 18 h / 20 °C
3.1: ethanol / 18 h / 20 °C
4.1: potassium carbonate / acetone / 2 h / 0 - 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C
6.1: potassium tert-butylate / ethanol / 36 h / Reflux
7.1: trichlorophosphate / N,N-dimethyl-formamide / 10 h / Reflux
8.1: N-ethyl-N,N-diisopropylamine / methanol / acetonitrile / 20 °C
9.1: ammonium chloride; iron / water; methanol / 1 h / 80 °C
10.1: sulfuric acid / 1-methyl-pyrrolidin-2-one / 24 h / 90 °C
With
sulfuric acid; potassium tert-butylate; hydrogen; iron; sodium hydride; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
methanol; palladium 10% on activated carbon; N,N-dimethyl-formamide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; acetic acid; acetone; acetonitrile;
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1356008-84-8
(+/-)-19-(4-fluorophenyl)-17-methyl-7-(3-methyl-1H-1,2,4-triazol-1-yl)-11,12,13,14,16,17,18,19-octahydro-10H-15,2-(azeno)-8,4-(metheno)pyrido[3,4-h][1,6,10,12]oxatriazacycloheptadecine trifluoroacetate
- Guidance literature:
-
Multi-step reaction with 9 steps
1: hydrogen; sulfuric acid / palladium 10% on activated carbon / acetic acid / 18 h / 20 °C
2: ethanol / 18 h / 20 °C
3: potassium carbonate / acetone / 2 h / 0 - 20 °C
4: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C
5: potassium tert-butylate / ethanol / 36 h / Reflux
6: trichlorophosphate / N,N-dimethyl-formamide / 10 h / Reflux
7: N-ethyl-N,N-diisopropylamine / methanol / acetonitrile / 20 °C
8: ammonium chloride; iron / water; methanol / 1 h / 80 °C
9: sulfuric acid / 1-methyl-pyrrolidin-2-one / 24 h / 90 °C
With
sulfuric acid; potassium tert-butylate; hydrogen; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
methanol; palladium 10% on activated carbon; N,N-dimethyl-formamide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; acetic acid; acetone; acetonitrile;
