ethyl 3-((3-ethoxy-3-oxopropyl)amino)-2-(4-fluorophenyl)propanoate

Base Information

• Chemical Name: ethyl 3-((3-ethoxy-3-oxopropyl)amino)-2-(4-fluorophenyl)propanoate
• CAS No.: 1263870-41-2
• Molecular Formula: C₁₆H₂₂FNO₄
• Molecular Weight: 311.353
• Mol file: 1263870-41-2.mol

Synonyms:ethyl 3-((3-ethoxy-3-oxopropyl)amino)-2-(4-fluorophenyl)propanoate

Chemical Property of ethyl 3-((3-ethoxy-3-oxopropyl)amino)-2-(4-fluorophenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-((3-ethoxy-3-oxopropyl)amino)-2-(4-fluorophenyl)propanoate

There total 5 articles about ethyl 3-((3-ethoxy-3-oxopropyl)amino)-2-(4-fluorophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl 3-amino-2-(4-fluorophenyl)propanoate + ethyl acrylate (140-88-5,9003-32-1) → ethyl 3-((3-ethoxy-3-oxopropyl)amino)-2-(4-fluorophenyl)propanoate (1263870-41-2)

Guidance literature:

In ethanol; at 20 ℃; for 18h;

Reference yield:

β-alanine ethyl ester hydrochloride + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + ethyl 2-(4-fluorophenyl)acetate (587-88-2) → ethyl 3-((3-ethoxy-3-oxopropyl)amino)-2-(4-fluorophenyl)propanoate (1263870-41-2)

Guidance literature:

N,N-dimethyl-formamide dimethyl acetal; ethyl 2-(4-fluorophenyl)acetate; In N,N-dimethyl-formamide; at 140 ℃; for 16h; Inert atmosphere;

β-alanine ethyl ester hydrochloride; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

With sodium tetrahydroborate; oxalic acid; acetic acid; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Cooling with ice; Reflux;

Reference yield:

ethyl β-alaninate hydrochloride (4244-84-2) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + ethyl 2-(4-fluorophenyl)acetate (587-88-2) → ethyl 3-((3-ethoxy-3-oxopropyl)amino)-2-(4-fluorophenyl)propanoate (1263870-41-2)

Guidance literature:

N,N-dimethyl-formamide dimethyl acetal; ethyl 2-(4-fluorophenyl)acetate; In N,N-dimethyl-formamide; at 140 ℃; for 16h; Inert atmosphere;

ethyl β-alaninate hydrochloride; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

upstream raw materials:

ethyl acrylate

4-fluorophenylacetonitrile

ethyl 2-cyano-2-(4-fluorophenyl)acetate

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

ethyl 3-((3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino)-2-(4-fluorophenyl)propanoate

ethyl 3-((3-ethoxy-3-oxopropyl)(methyl)amino)-2-(4-fluorophenyl)propanoate

tert-butyl 3-(4-fluorophenyl)-4-oxopiperidine-1-carboxylate

(+/-)-19-(4-fluorophenyl)-17-methyl-7-(3-methyl-1H-1,2,4-triazol-1-yl)-11,12,13,14,16,17,18,19-octahydro-10H-15,2-(azeno)-8,4-(metheno)pyrido[3,4-h][1,6,10,12]oxatriazacycloheptadecine trifluoroacetate