Z-Phe-D-Pro-Phe-N₂H₃

Base Information

Chemical Name:Z-Phe-D-Pro-Phe-N₂H₃
CAS No.:135481-65-1
Molecular Formula:C₃₁H₃₅N₅O₅
Molecular Weight:557.649
Hs Code.:

Z-Phe-D-Pro-Phe-N<sub>2</sub>H<sub>3</sub>

Synonyms:Z-Phe-D-Pro-Phe-N₂H₃

Suppliers and Price of Z-Phe-D-Pro-Phe-N₂H₃

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Z-Phe-D-Pro-Phe-N₂H₃

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Z-Phe-D-Pro-Phe-N₂H₃

There total 2 articles about Z-Phe-D-Pro-Phe-N₂H₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 135481-64-0
Z-Phe-D-Pro-Phe-OMe

: 135481-65-1
Z-Phe-D-Pro-Phe-N₂H₃

Guidance literature:: With hydrazine hydrate; In methanol; for 10h;
DOI:10.1021/ja00020a016

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 135481-65-1
Z-Phe-D-Pro-Phe-N₂H₃

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / NMM, HOBt, EDCI*HCl / tetrahydrofuran / -10 - 20 °C

2: 93 percent / hydrazine monohydrate / methanol / 10 h

With 4-methyl-morpholine; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol;
DOI:10.1021/ja00020a016

Reference yield:

: 135481-65-1
Z-Phe-D-Pro-Phe-N₂H₃

: 135481-68-4
cyclo<-D-Pro¹-Phe²-Ala³-Glu⁴-Phe⁵-Phe⁶->

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 36percent aq. HCl, isopentyl nitrite, 2.) DIPEA / 1.) DMA, -10 deg C, 1.5 h, 2.) DMA, 4 deg C, 12 h

2: hydrazine monohydrate / methanol / 16 h

3: H₂ / 10percent Pd/C / methanol; acetic acid

4: 1.) 36percent aq. HCl, isopentyl nitrite, 2.) DIPEA / 1.) DMF, -10 deg C, 1.5 h, 2.) DMF, 4 deg C, 5 d

5: 100 percent / gaseous HCl / diethyl ether / 0.5 h

With hydrogenchloride; hydrogen; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; isopentyl nitrite; palladium on activated charcoal; In methanol; diethyl ether; acetic acid;
DOI:10.1021/ja00020a016