2-Chloroethyl-a-methylbenzyl ether

Base Information

• Chemical Name: 2-Chloroethyl-a-methylbenzyl ether
• CAS No.: 1462-38-0
• Molecular Formula: C₁₀H₁₃ClO
• Molecular Weight: 184.666
• DSSTox Substance ID: DTXSID201301108
• Nikkaji Number: J44.192I
• Mol file: 1462-38-0.mol

Synonyms:1462-38-0;[1-(2-Chloroethoxy)ethyl]benzene;2-chloroethyl-a-methylbenzyl ether;DTXSID201301108;AKOS009293777

Chemical Property of 2-Chloroethyl-a-methylbenzyl ether

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 184.0654927
• Heavy Atom Count: 12
• Complexity: 110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)OCCCl

Technology Process of 2-Chloroethyl-a-methylbenzyl ether

There total 5 articles about 2-Chloroethyl-a-methylbenzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-Phenylethanol (98-85-1,13323-81-4) + 2-chloro-ethanol (107-07-3) → 2-chloroethyl 1-phenylethyl ether (1462-38-0)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; Heating;

DOI:10.1002/adsc.200606183

Reference yield:

(1-chloroethyl)benzene (672-65-1) + 2-chloro-ethanol (107-07-3) → 2-chloroethyl 1-phenylethyl ether (1462-38-0)

Guidance literature:

With sodium carbonate;

Reference yield:

2-methyl-1,3-dioxolane (497-26-7) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2-chloroethyl 1-phenylethyl ether (1462-38-0) + 2-chloroethyl phenethyl phosphorofluoridate

Guidance literature:

With phosphorus pentachloride; arsenic(III) fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1.) 2 d; 2.) ethanol, 10 deg C;

upstream raw materials:

(1-chloroethyl)benzene

2-chloro-ethanol

1-chloro-1-(2-chloro-ethoxy)-ethane

2-methyl-1,3-dioxolane

Downstream raw materials:

α-methylbenzyl vinyl ether