(1,1-Difluoro-2-phenyl-ethyl)-phosphonothioic acid O,O-dibenzyl ester

Base Information

• Chemical Name: (1,1-Difluoro-2-phenyl-ethyl)-phosphonothioic acid O,O-dibenzyl ester
• CAS No.: 176723-94-7
• Molecular Formula: C₂₂H₂₁F₂O₂PS
• Molecular Weight: 418.444
• Mol file: 176723-94-7.mol

Synonyms:(1,1-Difluoro-2-phenyl-ethyl)-phosphonothioic acid O,O-dibenzyl ester

Chemical Property of (1,1-Difluoro-2-phenyl-ethyl)-phosphonothioic acid O,O-dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1,1-Difluoro-2-phenyl-ethyl)-phosphonothioic acid O,O-dibenzyl ester

There total 4 articles about (1,1-Difluoro-2-phenyl-ethyl)-phosphonothioic acid O,O-dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzyl bromide (100-39-0) + dibenzyl α-lithio-α,α-difluoromethylenephosphonothioate (176724-19-9) → (1,1-Difluoro-2-phenyl-ethyl)-phosphonothioic acid O,O-dibenzyl ester (176723-94-7)

Guidance literature:

In tetrahydrofuran; at -41 ℃; for 4h;

DOI:10.1016/0040-4039(96)00238-9

Reference yield:

Dibenzyl phosphite (17176-77-1) → (1,1-Difluoro-2-phenyl-ethyl)-phosphonothioic acid O,O-dibenzyl ester (176723-94-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / NaH / tetrahydrofuran

2: 73 percent / Lawesson's Reagent / toluene

3: LiN(i-Pr)2 / tetrahydrofuran; hexane / -78 °C

4: 70 percent / tetrahydrofuran / 4 h / -41 °C

With Lawessons reagent; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene;

DOI:10.1016/0040-4039(96)00238-9

Reference yield:

dibenzyl (α-α-difluoromethyl)phosphonate (176724-17-7) → (1,1-Difluoro-2-phenyl-ethyl)-phosphonothioic acid O,O-dibenzyl ester (176723-94-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / Lawesson's Reagent / toluene

2: LiN(i-Pr)2 / tetrahydrofuran; hexane / -78 °C

3: 70 percent / tetrahydrofuran / 4 h / -41 °C

With Lawessons reagent; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene;

DOI:10.1016/0040-4039(96)00238-9

upstream raw materials:

benzyl bromide

dibenzyl α-lithio-α,α-difluoromethylenephosphonothioate

Dibenzyl phosphite

dibenzyl (α-α-difluoromethyl)phosphonate

Downstream raw materials:

perfluoro(5-azanon-4-ene)