Ethyl 4-cyano-3,5-diMethyl-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: Ethyl 4-cyano-3,5-diMethyl-1H-pyrrole-2-carboxylate
• CAS No.: 6297-38-7
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.217
• Hs Code.: 2933990090
• Mol file: 6297-38-7.mol

Synonyms:Pyrrole-2-carboxylicacid, 4-cyano-3,5-dimethyl-, ethyl ester (6CI,7CI,8CI); NSC 17444

Chemical Property of Ethyl 4-cyano-3,5-diMethyl-1H-pyrrole-2-carboxylate

Chemical Property:

• Vapor Pressure: 6.57E-05mmHg at 25°C
• Boiling Point: 344.5°C at 760 mmHg
• Flash Point: 162.1°C
• PSA: 65.88000
• Density: 1.17g/cm³
• LogP: 1.67988

Purity/Quality:

Ethyl4-cyano-3,5-dimethyl-1H-pyrrole-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-cyano-3,5-diMethyl-1H-pyrrole-2-carboxylate

There total 6 articles about Ethyl 4-cyano-3,5-diMethyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl 4-<(acetoxyperchloryl)thallio>-3,5-dimethylpyrrole-2-carboxylate (131992-08-0) → 3,5-dimethyl-2-ethoxycarbonyl-1H-pyrrole (2199-44-2) + ethyl 4-cyano-3,5-dimethylpyrrole-2-carboxylate (6297-38-7)

Guidance literature:

With potassium cyanide; In water; for 6h; Ambient temperature; Irradiation;

Reference yield:

4-carbamoyl-3,5-dimethyl-pyrrole-2-carboxylic acid ethyl ester (103386-45-4) → ethyl 4-cyano-3,5-dimethylpyrrole-2-carboxylate (6297-38-7)

Guidance literature:

With sodium acetate; acetic anhydride;

Reference yield:

4-chlorocarbonyl-3,5-dimethyl-pyrrole-2-carboxylic acid ethyl ester (52649-05-5) → ethyl 4-cyano-3,5-dimethylpyrrole-2-carboxylate (6297-38-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous NH₃

2: acetic acid anhydride

With ammonium hydroxide; acetic anhydride;

upstream raw materials:

4-carbamoyl-3,5-dimethyl-pyrrole-2-carboxylic acid ethyl ester

ethyl 4-<(acetoxyperchloryl)thallio>-3,5-dimethylpyrrole-2-carboxylate

4-cyano-3-hydroxymethyl-5-tribromomethyl-pyrrole-2-carboxylic acid ethyl ester

acetic acid

Downstream raw materials:

2,4-dimethyl-1H-pyrrole-3-carbonitrile

3-cyano-4-methyl-pyrrole-2,5-dicarboxylic acid-5-ethyl ester

5-Carboxy-3-cyan-2,4-dimethyl-pyrrol