1H-Pyrrole-3-carbonitrile,2,4-dimethyl-(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-3-carbonitrile,2,4-dimethyl-(9CI)
• CAS No.: 26187-28-0
• Molecular Formula: C7H8N2
• Molecular Weight: 120.154
• Hs Code.: 2933990090
• Mol file: 26187-28-0.mol

Synonyms:2,4-Dimethyl-3-cyanopyrrol;2,4-dimethyl-pyrrole-3-carbonitrile;2,4-Dimethyl-pyrrol-3-carbonitril;2,4-dimethyl-3-cyanopyrrole;3-cyano-2,4-dimethylpyrrole;1H-Pyrrole-3-carbonitrile,2,4-dimethyl;3-cyano-2,4-dimethyl-1H-pyrrole;

Chemical Property of 1H-Pyrrole-3-carbonitrile,2,4-dimethyl-(9CI)

Chemical Property:

• Melting Point: 107 °C
• Boiling Point: 264.6±35.0 °C(Predicted)
• PKA: 15.63±0.50(Predicted)
• PSA: 39.58000
• Density: 1.07±0.1 g/cm3(Predicted)
• LogP: 1.50318

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dimethyl-1H-pyrrole-3-carbonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-3-carbonitrile,2,4-dimethyl-(9CI)

There total 17 articles about 1H-Pyrrole-3-carbonitrile,2,4-dimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C7H10N2O (910225-64-8) → 2,4-dimethyl-1H-pyrrole-3-carbonitrile (26187-28-0)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 ℃; for 0.5h;

DOI:10.1021/ja5020053

Reference yield:

3-Aminocrotononitrile (1118-61-2) + methylmagnesium bromide (75-16-1) + glycine N'-methoxy-N'-methylamide hydrobromide salt → 2,4-dimethyl-1H-pyrrole-3-carbonitrile (26187-28-0)

Guidance literature:

3-Aminocrotononitrile; glycine N'-methoxy-N'-methylamide hydrobromide salt; In ethanol; at 20 ℃; for 16h; Inert atmosphere;

methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -10 ℃; for 1.83333h; Inert atmosphere;

With sodium ethanolate; In ethanol; at 20 ℃; for 0.5h;

Reference yield:

(E)-3-(2-Oxo-propylamino)-but-2-enenitrile → 2,4-dimethyl-1H-pyrrole-3-carbonitrile (26187-28-0)

Guidance literature:

With sodium ethanolate; In ethanol; at 0 ℃; for 1h;

DOI:10.1021/ja061972v

upstream raw materials:

5-Carboxy-3-cyan-2,4-dimethyl-pyrrol

ethyl 4-cyano-3,5-dimethylpyrrole-2-carboxylate

4-carbamoyl-3,5-dimethyl-pyrrole-2-carboxylic acid ethyl ester

3-Aminocrotononitrile