(2,3-Difluoro-4-(octyloxy)phenyl)boronic acid

Base Information

Chemical Name:(2,3-Difluoro-4-(octyloxy)phenyl)boronic acid
CAS No.:121219-22-5
Molecular Formula:C14H21 B F2 O3
Molecular Weight:286.127
Hs Code.:
DSSTox Substance ID:DTXSID70445843
Nikkaji Number:J2.157.486D
Wikidata:Q82264378
Mol file:121219-22-5.mol

Synonyms:121219-22-5;(2,3-Difluoro-4-(octyloxy)phenyl)boronic acid;(2,3-difluoro-4-octoxyphenyl)boronic acid;[2,3-Difluoro-4-(octyloxy)phenyl]boronic acid;2,3-DIFLUORO-4-(OCTYLOXY)-BENZENEBORONIC ACID;starbld0019314;2,3-Difluoro-4-n-octoxyphenylboronic acid;SCHEMBL4827415;DTXSID70445843;GUGMXTUFYGIPHU-UHFFFAOYSA-N;2,3-difluro-4-octoxyphenylboronic acid;2,3-difluoro4-octyloxyphenylboronic acid;2,3-difluoro-4-octyloxyphenylboronic acid;2,3-DIFLUORO-4-(OCTYLOXY)PHENYLBORONIC ACID

Suppliers and Price of (2,3-Difluoro-4-(octyloxy)phenyl)boronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (2,3-Difluoro-4-(octyloxy)phenyl)boronic acid

Chemical Property:

PSA：49.69000
LogP:2.38390
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:286.1551810
Heavy Atom Count:20
Complexity:257

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:B(C1=C(C(=C(C=C1)OCCCCCCCC)F)F)(O)O

Technology Process of (2,3-Difluoro-4-(octyloxy)phenyl)boronic acid

There total 11 articles about (2,3-Difluoro-4-(octyloxy)phenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 121219-21-4
2,3-difluoro-1-n-octyloxybenzene

: 121219-22-5
4-n-octyloxy-2,3-difluorophenyl boronic acid

Guidance literature:: 2,3-difluoro-1-n-octyloxybenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h; Inert atmosphere;

With Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1039/c4nj00426d

Reference yield:

: 121-43-7,63156-11-6
Trimethyl borate

: 121219-21-4
2,3-difluoro-1-n-octyloxybenzene

: 121219-22-5
4-n-octyloxy-2,3-difluorophenyl boronic acid

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

: 6418-38-8
2,3-difluorophenol

: 121219-22-5
4-n-octyloxy-2,3-difluorophenyl boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / K₂CO₃ / acetone / 12 h / Heating

2: n-BuLi / tetrahydrofuran / -70 °C

3: aq. HCl

With hydrogenchloride; n-butyllithium; potassium carbonate; In tetrahydrofuran; acetone;
DOI:10.1016/j.tetlet.2005.02.084