phosphoric acid dibenzyl ester 2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]-amino}-ethyl ester

Base Information

Chemical Name:phosphoric acid dibenzyl ester 2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]-amino}-ethyl ester
CAS No.:1426899-88-8
Molecular Formula:C₃₆H₃₅N₂O₇PS
Molecular Weight:670.723
Hs Code.:

Synonyms:phosphoric acid dibenzyl ester 2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]-amino}-ethyl ester

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Chemical Property of phosphoric acid dibenzyl ester 2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]-amino}-ethyl ester

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Technology Process of phosphoric acid dibenzyl ester 2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]-amino}-ethyl ester

There total 11 articles about phosphoric acid dibenzyl ester 2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]-amino}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1426899-28-6
2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid (2-hydroxy-ethyl)-amide

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1426899-88-8
phosphoric acid dibenzyl ester 2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]-amino}-ethyl ester

Guidance literature:: 2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid (2-hydroxy-ethyl)-amide; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In dichloromethane; acetonitrile; at 0 ℃; for 1.16667h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile; at 0 ℃; for 0.166667h;

Reference yield: 80.0%

: 1426899-86-6
2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid (2-hydroxy-ethyl)-amide

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1426899-88-8
phosphoric acid dibenzyl ester 2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]-amino}-ethyl ester

Guidance literature:: 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid (2-hydroxy-ethyl)-amide; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In dichloromethane; acetonitrile; at 0 ℃; for 1.16667h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile; at 0 ℃; for 0.166667h;

Reference yield:

: 1426899-85-5
2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt

: 1426899-88-8
phosphoric acid dibenzyl ester 2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]-amino}-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 16 h

2.1: 1H-tetrazole / dichloromethane; acetonitrile / 1.17 h / 0 °C

2.2: 0.17 h / 0 °C

With 4-methyl-morpholine; 1H-tetrazole; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;