2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt

Base Information

Chemical Name:2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt
CAS No.:1426899-85-5
Molecular Formula:C₂₀H₁₆NO₄S*Li
Molecular Weight:373.358
Hs Code.:

Synonyms:2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt

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Chemical Property of 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt

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Technology Process of 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt

There total 10 articles about 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1426899-84-4
2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid methyl ester

: 1426899-85-5
2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 3h;

Reference yield:

6-bromo-2-o-tolyl-chroman-4-one: 1426899-75-3
6-bromo-2-o-tolyl-chroman-4-one

: 1426899-85-5
2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 1 h / Reflux

2.1: trifluoroacetic acid; triethylsilane / dichloromethane / 2.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C

3.2: 1 h / -78 °C

3.3: 0.25 h / 20 - 30 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 50 °C

5.1: lithium hydroxide / methanol; water; tetrahydrofuran / 3 h / 20 °C

With triethylsilane; n-butyllithium; borane-THF; potassium carbonate; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide;

Reference yield:

: 529-20-4
2-methylphenyl aldehyde

: 1426899-85-5
2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / ethanol / 3 h / 50 °C

2.1: hydrogenchloride / ethanol; water / 5 h / Reflux

3.1: borane-THF / tetrahydrofuran / 1 h / Reflux

4.1: trifluoroacetic acid; triethylsilane / dichloromethane / 2.5 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C

5.2: 1 h / -78 °C

5.3: 0.25 h / 20 - 30 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 50 °C

7.1: lithium hydroxide / methanol; water; tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; triethylsilane; n-butyllithium; borane-THF; potassium carbonate; trifluoroacetic acid; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide;