((1S,2R,3S)-2-Hydroxymethyl-3-phenyl-cyclopropyl)-morpholin-4-yl-methanone

Base Information

Chemical Name:((1S,2R,3S)-2-Hydroxymethyl-3-phenyl-cyclopropyl)-morpholin-4-yl-methanone
CAS No.:141506-56-1
Molecular Formula:C₁₅H₁₉NO₃
Molecular Weight:261.321
Hs Code.:

Synonyms:((1S,2R,3S)-2-Hydroxymethyl-3-phenyl-cyclopropyl)-morpholin-4-yl-methanone

Suppliers and Price of ((1S,2R,3S)-2-Hydroxymethyl-3-phenyl-cyclopropyl)-morpholin-4-yl-methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of ((1S,2R,3S)-2-Hydroxymethyl-3-phenyl-cyclopropyl)-morpholin-4-yl-methanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of ((1S,2R,3S)-2-Hydroxymethyl-3-phenyl-cyclopropyl)-morpholin-4-yl-methanone

There total 10 articles about ((1S,2R,3S)-2-Hydroxymethyl-3-phenyl-cyclopropyl)-morpholin-4-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 130780-69-7,141041-95-4,141506-48-1,141506-56-1
1-(4-morpholinylcarbonyl)-2-(hydroxymethyl)-3-phenylcyclopropane

: 130780-69-7,141041-95-4,141506-48-1,141506-56-1
((1S,2S,3R)-2-Hydroxymethyl-3-phenyl-cyclopropyl)-morpholin-4-yl-methanone

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; for 1h; Ambient temperature;
DOI:10.1021/jm960059+

Reference yield: 81.0%

: 130780-74-4
C₆H₁₄AlNO

: 88539-24-6,130855-58-2,132435-60-0,132435-61-1,141041-89-6,141506-44-7
endo-6-phenyl-3-oxabicyclo<3.1.0>hexan-2-one

: 130780-69-7,141041-95-4,141506-48-1,141506-56-1
1-(4-morpholinylcarbonyl)-2-(hydroxymethyl)-3-phenylcyclopropane

Guidance literature:: In dichloromethane; at 40 ℃; for 48h;
DOI:10.1016/S0040-4039(00)97718-9

Reference yield:

: 130780-62-0
cis-3-phenyl-2-propen-1-yl diazoacetate

: 130780-69-7,141041-95-4,141506-48-1,141506-56-1
((1S,2S,3R)-2-Hydroxymethyl-3-phenyl-cyclopropyl)-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / bis(N-tert-butylsalicylaldiminato)copper(II) / toluene / 12 h / Heating

2: 1.) AlMe₃ / 1.) hexane, CH₂Cl₂, RT, 20 min, 2.) hexane, CH₂Cl₂, 40 deg C, 20 h

3: 88 percent / lithium hexamethyl disilazide / tetrahydrofuran; hexane / 1 h / Ambient temperature

With bis(N-tert-butylsalicylaldiminato)copper(II); trimethylaluminum; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jm960059+