N⁵-(2-(4-(3-fluorophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine

Base Information

• Chemical Name: N⁵-(2-(4-(3-fluorophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine
• CAS No.: 1608157-11-4
• Molecular Formula: C₂₀H₂₂FN₉O
• Molecular Weight: 423.453

Synonyms:N⁵-(2-(4-(3-fluorophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine

Chemical Property of N⁵-(2-(4-(3-fluorophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine

Chemical Property:

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Technology Process of N⁵-(2-(4-(3-fluorophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine

There total 6 articles about N⁵-(2-(4-(3-fluorophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

C12H18FN3 (1240266-95-8) + LUF5443 (139181-27-4) → N5-(2-(4-(3-fluorophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine (1608157-11-4)

Guidance literature:

LUF₅₄₄₃; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃;

C₁₂H₁₈FN₃; In acetonitrile; Reflux;

DOI:10.1002/cmdc.201300474

Reference yield:

1-(3-fluorophenyl)piperazine (3801-89-6) → N5-(2-(4-(3-fluorophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine (1608157-11-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C

2.1: hydrazine hydrate / ethanol / 70 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

3.2: Reflux

With potassium carbonate; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201300474

Reference yield:

2-furoic acid hydrazide (3326-71-4) → N5-(2-(4-(3-fluorophenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine (1608157-11-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 72 h / 20 °C

2.1: water; ethyl acetate / 3 h / 20 °C

3.1: dichloromethane; methanol / 5.5 h / 20 - 180 °C / Inert atmosphere; Reflux

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

4.2: Reflux

With 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In methanol; dichloromethane; water; ethyl acetate;

DOI:10.1002/cmdc.201300474

upstream raw materials:

1-(3-fluorophenyl)piperazine

2-furoic acid hydrazide

2-(2-(4-(3-fluorophenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

N-(furan-2-ylcarbonyl)carbonohydrazonic diamide

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