HEPTAKIS-(2,6-DI-O-PENTYL)-BETA-CYCLODEXTRIN

Base Information

• Chemical Name: HEPTAKIS-(2,6-DI-O-PENTYL)-BETA-CYCLODEXTRIN
• CAS No.: 121801-65-8
• Molecular Formula: C112H210 O35
• Molecular Weight: 2116.84
• Mol file: 121801-65-8.mol

Synonyms:2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane,b-cyclodextrin deriv.;2,6-Di-O-pentyl-b-cyclodextrin;Heptakis(2,6-di-O-pentyl)-b-cyclodextrin; Heptakis(2,6-dipentyl)-b-cyclodextrin

Chemical Property of HEPTAKIS-(2,6-DI-O-PENTYL)-BETA-CYCLODEXTRIN

Chemical Property:

• PSA: 400.05000
• LogP: 15.77240

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of HEPTAKIS-(2,6-DI-O-PENTYL)-BETA-CYCLODEXTRIN

There total 1 articles about HEPTAKIS-(2,6-DI-O-PENTYL)-BETA-CYCLODEXTRIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-Bromopentane (110-53-2) + β‐cyclodextrin (7585-39-9) → heptakis(2,6-di-O-pentyl)-β-cyclodextrin (121801-65-8)

Guidance literature:

In 1,4-dioxane; N,N-dimethyl-formamide; at 50 ℃; for 12h;

DOI:10.1002/mrc.1260290709

Reference yield: 46.0%

benzyl bromide (100-39-0) + heptakis(2,6-di-O-pentyl)-β-cyclodextrin (121801-65-8) → heptakis(3-O-benzyl-2,6-di-O-pentyl)-β-cyclodextrin (143571-33-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; 1,4-dioxane; at 80 ℃; for 144h;

Reference yield:

acetic anhydride (108-24-7) + heptakis(2,6-di-O-pentyl)-β-cyclodextrin (121801-65-8) → Lipodex D (heptakis(3-O-acetyl-2,6-di-O-pentyl)cyclomaltoheptaose) (120614-93-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 96h; Heating;

DOI:10.1016/0008-6215(89)85164-X

upstream raw materials:

1-Bromopentane

β‐cyclodextrin

Downstream raw materials:

Lipodex D (heptakis(3-O-acetyl-2,6-di-O-pentyl)cyclomaltoheptaose)

heptakis(3-O-benzyl-2,6-di-O-pentyl)-β-cyclodextrin

heptakis(2,6-di-O-pentyl)-β-cyclodextrin hepta(3-phenylcarbamate)

Refernces

• 1、 Meier-Augenstein, Wolfram,Burger, Barend V.,Spies, Hendrik S. C.. "NMR Spectroscopic Properties of Heptakis(2,6-di-O-pentyl)-β-Cyclodextrin: Two-Dimensional NMR Spectra of a Key Intermediate in Preparing Chiral Stationary Phases for Enantioselective Capillary Gas Chromatography". . p. 681 - 686. Retrieved 1991.
• 2、 Takeichi, Tsutomu,Shimura, Sigeru,Toriyama, Hisashi,Takayama, Yuzi,Morikawa, Masami. "Carbamate Derivatives of β-Cyclodextrin as Chiral Stationary Phases for Metal Capillary Gas Chromatography". . p. 1069 - 1072. Retrieved 2007/10/02.