(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-cyano-3-phenylpropanoate

Base Information

Chemical Name:(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-cyano-3-phenylpropanoate
CAS No.:174061-36-0
Molecular Formula:C₃₂H₄₇N₃O₄S
Molecular Weight:569.809
Hs Code.:

Synonyms:(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-cyano-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-cyano-3-phenylpropanoate

Chemical Property:

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Technology Process of (2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-cyano-3-phenylpropanoate

There total 1 articles about (2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-cyano-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 188183-31-5
(2RS)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 3-phenyl-2-cyanopropanoate

: 174061-36-0
(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-cyano-3-phenylpropanoate

: 158149-97-4
(2S)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-cyano-3-phenylpropanoate

Guidance literature:: With O-(diphenylphosphinyl)hydroxylamine; lithium diisopropyl amide; In tetrahydrofuran; Product distribution; multistep reaction; other bases, other reagents;
DOI:10.1016/0957-4166(94)80114-2

Reference yield: 85.0%

: 174061-36-0
(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-cyano-3-phenylpropanoate

: (2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-aminomethyl-3-phenylpropanoate

Guidance literature:: With ammonia; hydrogen; Rh/Al₂O₃; In ethanol; at 25 ℃; for 16h; under 760 Torr;
DOI:10.1016/0957-4166(95)00368-Y

Reference yield:

: 174061-36-0
(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-cyano-3-phenylpropanoate

: (2R)-2-amino-2-aminomethyl-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / H₂, NH₃ / Rh/Al₂O₃ / ethanol / 16 h / 25 °C / 760 Torr

2: 95 percent / 10percent KOH / methanol / 5 h / Heating

With potassium hydroxide; ammonia; hydrogen; Rh/Al₂O₃; In methanol; ethanol;
DOI:10.1016/0957-4166(95)00368-Y