6-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-cyclohex-2-enone

Base Information

• Chemical Name: 6-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-cyclohex-2-enone
• CAS No.: 863997-71-1
• Molecular Formula: C₂₀H₃₀O₄Si
• Molecular Weight: 362.541
• Mol file: 863997-71-1.mol

Synonyms:6-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-cyclohex-2-enone

Chemical Property of 6-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-cyclohex-2-enone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-cyclohex-2-enone

There total 26 articles about 6-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-cyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4-(4-methoxy-benzyloxy)-cyclohexanone (863997-70-0) → 6-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-cyclohex-2-enone (863997-71-1)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.tet.2006.05.022

Reference yield: 99.0%

6-hydroxy-4-(4-methoxy-benzyloxy)-cyclohex-2-enone (863997-72-2) + tert-butyldimethylsilyl chloride (18162-48-6) → 6-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-cyclohex-2-enone (863997-71-1)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 25 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/anie.201410369

Reference yield: 89.0%

(4S,6S)-4-(tert-butyldimethylsilyloxy)-6-(4-methoxybenzyloxy)octa-1,7-dien-3-one (1313275-49-8) → 6-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-cyclohex-2-enone (863997-71-1)

Guidance literature:

Hoveyda-Grubbs catalyst second generation; In benzene; at 23 ℃; for 0.666667h; Inert atmosphere; Heating;

upstream raw materials:

2-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4-(4-methoxy-benzyloxy)-cyclohexanone

tert-butyl-[6-methoxy-5-(4-methoxy-benzyloxy)-2-methylene-tetrahydro-pyran-3-yloxy]-dimethyl-silane

tert-Butyl-[(2S,3S,5S,6S)-2-iodomethyl-6-methoxy-5-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yloxy]-dimethyl-silane

t-butyldimethylsiyl triflate

Downstream raw materials:

6-hydroxy-4-(4-methoxy-benzyloxy)-cyclohex-2-enone

(diethoxy-phosphoryl)-acetic acid 5-(4-methoxy-benzyloxy)-2-oxo-cyclohex-3-enyl ester

6-(4-methoxy-benzyloxy)-7,7a-dihydro-6H-benzofuran-2-one

C₃₅H₄₆O₈Si