4-formylbenzyl methanesulfonate

Base Information

• Chemical Name: 4-formylbenzyl methanesulfonate
• CAS No.: 758717-04-3
• Molecular Formula: C₉H₁₀O₄S
• Molecular Weight: 214.242
• Mol file: 758717-04-3.mol

Synonyms:4-formylbenzyl methanesulfonate

Chemical Property of 4-formylbenzyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-formylbenzyl methanesulfonate

There total 2 articles about 4-formylbenzyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanesulfonyl chloride (124-63-0) + 4-(hydroxylmethyl)benzaldehyde (52010-97-6) → 4-formylbenzyl methanesulfonate (758717-04-3)

Guidance literature:

With triethylamine; In dichloromethane; at -5 ℃; for 0.25h;

DOI:10.1007/s11172-005-0076-z

Reference yield:

terephthalaldehyde, (623-27-8) → 4-formylbenzyl methanesulfonate (758717-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / NaBH₄; EtOH / tetrahydrofuran / 6.5 h / -5 - 2 °C

2: 95 percent / triethylamine / CH₂Cl₂ / 0.25 h / -5 °C

With sodium tetrahydroborate; ethanol; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1007/s11172-005-0076-z

Reference yield: 79.0%

4-formylbenzyl methanesulfonate (758717-04-3) + dimethylfumarate (624-49-7) → C14H16O5

Guidance literature:

With 2,6-dimethylpyridine; crithmene; potassium 5-bromo-1H-indole-1-carbodithioate; In acetonitrile; at 60 ℃; for 24h; Irradiation;

DOI:10.1038/s41557-018-0173-x

upstream raw materials:

methanesulfonyl chloride

4-(hydroxylmethyl)benzaldehyde

terephthalaldehyde,

Downstream raw materials:

3,5-bis(4-formylbenzyloxy)benzyl alcohol

1-formyl-4-(fluoromethyl)benzene