Benzene,1-chloro-2,4,5-trifluoro-3-(trifluoromethyl)-

Base Information

• Chemical Name: Benzene,1-chloro-2,4,5-trifluoro-3-(trifluoromethyl)-
• CAS No.: 122030-03-9
• Molecular Formula: C7H Cl F6
• Molecular Weight: 234.528
• Hs Code.: 2903999090
• Mol file: 122030-03-9.mol

Synonyms:2,5,6-TRIFLUORO-3-CHLORO-BENZOTRIFLUORIDE;1-CHLORO-2,4,5-TRIFLUORO-3-TRIFLUOROMETHYL-BENZENE;3-CHLORO-2,5,6-TRIFLUORO-BENZOTRIFLUORIDE;5-CHLORO-2,3,6-TRIFLUOROBENZOTRIFLUORIDE;5-CHLORO-2,3,6-TRIFLUOROBENZOTRIFLUOROIDE

Chemical Property of Benzene,1-chloro-2,4,5-trifluoro-3-(trifluoromethyl)-

Chemical Property:

• Refractive Index: 1.404
• PSA: 0.00000
• LogP: 3.77610

Purity/Quality:

98%min ^*data from raw suppliers

SG000194:1-Chloro-2,4,5-trifluoro-3-trifluoromethyl-benzene 98 ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene,1-chloro-2,4,5-trifluoro-3-(trifluoromethyl)-

There total 4 articles about Benzene,1-chloro-2,4,5-trifluoro-3-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

2,3,5-trifluoro-4-trifluoromethyl-6-chlorobenzenethiol (1217087-00-7) → 1-chloro-2,4,5-trifluoro-3-(trifluoromethyl)benzene (122030-03-9) + 4-chloro-3,6-difluoro-2-trifluoromethylphenol

Guidance literature:

With chloroform; sodium hydroxide; In 1,4-dioxane; water; at 48 - 54 ℃; for 21h;

DOI:10.1134/S1070428015110068

Reference yield:

1-trifluoromethyl-2,4,5,6-tetrafluoro-3-chlorobenzene (4284-09-7) → 4-trifluoromethyl-1,2,3,5-tetrafluorobenzene (5360-82-7) + 1-chloro-2,4,5-trifluoro-3-(trifluoromethyl)benzene (122030-03-9)

Guidance literature:

1-trifluoromethyl-2,4,5,6-tetrafluoro-3-chlorobenzene; With 2-H-3-chlorohexafluorotoluene; tin(ll) chloride; zinc; In N,N-dimethyl-formamide; at 70 ℃; for 8h; closed flask;

With hydrogenchloride; In N,N-dimethyl-formamide;

DOI:10.1070/MC2006v016n03ABEH002266

Reference yield:

1-trifluoromethyl-2,4,5,6-tetrafluoro-3-chlorobenzene (4284-09-7) → 1-bromo-2-chloro-3,5,6-trifluoro-4-(trifluoromethyl)benzene + 4-trifluoromethyl-1,2,3,5-tetrafluorobenzene (5360-82-7) + 1-bromo-2,3,4,6-tetrafluoro-5-(trifluoromethyl)benzene (5360-80-5) + 1-chloro-2,4,5-trifluoro-3-(trifluoromethyl)benzene (122030-03-9)

Guidance literature:

1-trifluoromethyl-2,4,5,6-tetrafluoro-3-chlorobenzene; With 2-H-3-chlorohexafluorotoluene; tin(ll) chloride; zinc; In N,N-dimethyl-formamide; at 70 ℃; for 27h; closed flask;

With bromine; N,N-dimethyl-formamide; steam distillation;

DOI:10.1070/MC2006v016n03ABEH002266

upstream raw materials:

1-trifluoromethyl-2,4,5,6-tetrafluoro-3-chlorobenzene

2,3,5-trifluoro-4-trifluoromethyl-6-chlorobenzenethiol

Refernces

• 1、 Bredikhin,Maksimov,Gatilov, Yu. V.,Kireenkov,Platonov. "Reactions of polyfluorobenzenethiols with polyhalomethanes and their derivatives in an alkaline medium". . p. 1551 - 1559. Retrieved 2015/12/30.