21508-19-0

Basic information

• Product Name: 5-CHLORO-2-FURALDEHYDE
• Synonyms: TIMTEC-BB SBB004223;5-CHLORO-2-FURALDEHYDE;5-chlorofuran-2-carboxaldehyde;5-CHLORO-2-FURALDEHYDE,97%;5-CHLORO-2-FURALDEHYDE, 98+%;5-Chloro-2-furaldehyde, 98%, stab. with 2% ethanol;5-Chloro-2-furaldehyde,97%,stabilized;5-Chloro-2-furaldehyde, stabilized, 97%
• CAS NO: 21508-19-0
• Molecular Formula: C₅H₃ClO₂
• Molecular Weight: 130.53
• EINECS: -0
• Product Categories: Building Blocks;Furans;FuransHeterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Aldehydes;Building Blocks;C1 to C6;C4 to C7;C4 to C8;Carbonyl Compounds;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Organic Building Blocks
• Mol File: 21508-19-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 34-37 °C(lit.)
• Boiling Point: 70°C 10mm
• Flash Point: 190 °F
• Appearance: White to off-white/Crystalline Powder
• Density: 1.361 g/cm³
• Vapor Pressure: 0.553mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: 2-8°C
• Solubility: Acetone (Slightly), Methanol (Slightly)
• Water Solubility: Insoluble in water.
• Sensitive: Air Sensitive
• BRN: 108401
• CAS DataBase Reference: 5-CHLORO-2-FURALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-FURALDEHYDE(21508-19-0)
• EPA Substance Registry System: 5-CHLORO-2-FURALDEHYDE(21508-19-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 21508-19-0(Hazardous Substances Data)

Usage

Chemical Properties

White to yellow powder

Uses

Different sources of media describe the Uses of 21508-19-0 differently. You can refer to the following data:
1. (+)-1-Deoxynojirimycin hydrochloride interferes with normal processing of N-linked glycoproteins, producing reduced amounts of complex type oligosaccharides.
2. 5-Chloro-2-furaldehyde may be used as an internal standard during the analysis of furanic compounds by reversed-phase-high performance liquid chromatography–diode array detection (RP-HPLC–DAD) method.

General Description

5-Chloro-2-furaldehyde is also known as 5-chlorofurfural. It reacts with aniline and aniline hydrochloride to form bis-(phenylamino) derivatives, without the furan ring cleavage. It also undergoes coupling with ethyl acetoacetate to form the corresponding ethyl bis-acetoacetate.

InChI:InChI=1/C5H3ClO2/c6-5-2-1-4(3-7)8-5/h1-3H

Upstream product

• 1137088-24-4 (5-formylfuran-2-yl)(triphenyl-λ5-phosphanyl)gold 
• 698-63-5 5-nitrofurane-2-carboxaldehyde 
• 618-30-4 5-chlorofuran-2-carboxylic acid 
• 75-15-0 carbon disulfide 
• 7791-25-5 sulfuryl dichloride 
• 613-75-2 (furan-2-yl)methylene diacetate 
• 98-01-1 furfural 
• 24078-79-3 5-chlorofuran-2-carbonyl chloride 

Downstream Products

• 67-47-0 5-hydroxymethyl-2-furfuraldehyde 
• 24078-79-3 5-chlorofuran-2-carbonyl chloride 

Relevant articles and documents

Bifunctional Furfuryl Cations Strategy: Three-Component Synthesis of Enamidyl Triazoles

A new multicomponent synthesis of functionalized enamidyl triazoles starting from simple and readily available starting materials is described. A simple treatment of a dichloromethane solution of an azide, amine, and 5-bromo-2-furylcarbinol with a Lewis acid provides the enamidyl triazole in good to high yield. A triple domino sequence, formal [3+2] cycloaddition/ring-opening/amidation, is involved in this new skeleton-generating reaction.

Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the heat shock protein 90 kDa (Hsp90) family of molecular chaperones. Grp94 associates with many proteins involved in cell adhesion and signaling, including integrins, Toll-like receptors, immunoglobulins, and mutant myocilin. Grp94 has been implicated as a target for several therapeutic areas including glaucoma, cancer metastasis, and multiple myeloma. While 85% identical to other Hsp90 isoforms, the N-terminal ATP-binding site of Grp94 possesses a unique hydrophobic pocket that was used to design isoform-selective inhibitors. Incorporation of a cis-amide bioisostere into the radamide scaffold led to development of the original Grp94-selective inhibitor, BnIm. Structure-activity relationship studies have now been performed on the aryl side chain of BnIm, which resulted in improved analogues that exhibit better potency and selectivity for Grp94. These analogues also manifest superior antimigratory activity in a metastasis model as well as enhanced mutant myocilin degradation in a glaucoma model compared to BnIm.

THIADIAZOLES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of Formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of Formula (IA).