N-(4-(2,4-dimethylphenyl)-3-methylthiazol-2(3H)-ylidene)thiophene-2-carboxamide

Base Information

Chemical Name:N-(4-(2,4-dimethylphenyl)-3-methylthiazol-2(3H)-ylidene)thiophene-2-carboxamide
CAS No.:1421376-26-2
Molecular Formula:C₁₇H₁₆N₂OS₂
Molecular Weight:328.459
Hs Code.:

Synonyms:N-(4-(2,4-dimethylphenyl)-3-methylthiazol-2(3H)-ylidene)thiophene-2-carboxamide

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Chemical Property of N-(4-(2,4-dimethylphenyl)-3-methylthiazol-2(3H)-ylidene)thiophene-2-carboxamide

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Technology Process of N-(4-(2,4-dimethylphenyl)-3-methylthiazol-2(3H)-ylidene)thiophene-2-carboxamide

There total 2 articles about N-(4-(2,4-dimethylphenyl)-3-methylthiazol-2(3H)-ylidene)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 312743-68-3
C₁₆H₁₄N₂OS₂

: 74-88-4
methyl iodide

: 1421376-16-0
C₁₇H₁₆N₂OS₂

: 1421376-26-2
N-(4-(2,4-dimethylphenyl)-3-methylthiazol-2(3H)-ylidene)thiophene-2-carboxamide

Guidance literature:: C₁₆H₁₄N₂OS₂; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 2h;
DOI:10.1021/ml300322n

Reference yield:

: 26346-85-0
2-bromo-1-(2,4-dimethylphenyl)ethanone

: 1421376-26-2
N-(4-(2,4-dimethylphenyl)-3-methylthiazol-2(3H)-ylidene)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 1 h / Reflux

2.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.33 h / 0 - 20 °C

3.2: 2 h / 0 - 20 °C

With dmap; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; mineral oil;
DOI:10.1021/ml300322n