1-[2-(6,7-dimethoxy-4,4-dimethyl-isochroman-1-yl)-ethyl]-4-phenyl-piperazine

Base Information

• Chemical Name: 1-[2-(6,7-dimethoxy-4,4-dimethyl-isochroman-1-yl)-ethyl]-4-phenyl-piperazine
• CAS No.: 70822-30-9
• Molecular Formula: C₂₅H₃₄N₂O₃
• Molecular Weight: 410.557

Synonyms:1-[2-(6,7-dimethoxy-4,4-dimethyl-isochroman-1-yl)-ethyl]-4-phenyl-piperazine

Chemical Property of 1-[2-(6,7-dimethoxy-4,4-dimethyl-isochroman-1-yl)-ethyl]-4-phenyl-piperazine

Chemical Property:

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Technology Process of 1-[2-(6,7-dimethoxy-4,4-dimethyl-isochroman-1-yl)-ethyl]-4-phenyl-piperazine

There total 3 articles about 1-[2-(6,7-dimethoxy-4,4-dimethyl-isochroman-1-yl)-ethyl]-4-phenyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

4-phenyl-1-piperazine (92-54-6) + 1-(2-chloroethyl)-4,4-dimethyl-6,7-dimethoxyisochroman (70822-39-8) → 1-[2-(6,7-dimethoxy-4,4-dimethyl-isochroman-1-yl)-ethyl]-4-phenyl-piperazine (70822-30-9)

Guidance literature:

In ethylene glycol; at 50 - 70 ℃; for 20h;

DOI:10.1021/jm00343a015

Reference yield:

2-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol (70822-01-4) → 1-[2-(6,7-dimethoxy-4,4-dimethyl-isochroman-1-yl)-ethyl]-4-phenyl-piperazine (70822-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / BH₃*Et₂O / nitromethane / 3 h / 22 °C

2: 27 percent / ethane-1,2-diol / 20 h / 50 - 70 °C

With tetrafluoroboric acid-diethyl ether complex; In nitromethane; ethylene glycol;

DOI:10.1021/jm00343a015

Reference yield:

→ 1-[2-(6,7-dimethoxy-4,4-dimethyl-isochroman-1-yl)-ethyl]-4-phenyl-piperazine (70822-30-9)

Guidance literature:

entspr. 1-(2-Chlorethyl)isochroman, 1-Phenylpiperazin-Et3N;

upstream raw materials:

4-phenyl-1-piperazine

1-(2-chloroethyl)-4,4-dimethyl-6,7-dimethoxyisochroman

2-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol

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