N-Trityl Candesartan

Base Information

• Chemical Name: N-Trityl Candesartan
• CAS No.: 894806-43-0
• Molecular Formula: C₄₃H₃₄N₆O₃
• Molecular Weight: 682.781
• Mol file: 894806-43-0.mol

Synonyms:2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylic acid

Chemical Property of N-Trityl Candesartan

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

N-TritylCandesartan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Trityl Candesartan

There total 1 articles about N-Trityl Candesartan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

trityl chloride (76-83-5) + candesartan (139481-59-7) → 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylic acid (894806-43-0)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jm00068a011

Reference yield:

copper(II) choride dihydrate + 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylic acid (894806-43-0) → [Cu2(trityl candesartan)4(H2O)2]*4H2O

Guidance literature:

With sodium hydroxide; In ethanol; water; at 70 ℃; pH=7;

DOI:10.1016/j.jinorgbio.2013.02.005

Reference yield:

Chloromethyl acetate (625-56-9) + 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylic acid (894806-43-0) → 2-Ethoxy-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid acetoxymethyl ester

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

DOI:10.1021/jm00068a011

upstream raw materials:

trityl chloride

candesartan

Downstream raw materials:

2-Ethoxy-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid 1-cyclohexyloxycarbonyloxy-ethyl ester