625-56-9

Basic information

• Product Name: Chloromethyl acetate
• Synonyms: Methanol, chloro-, acetate;CHLOROMETHYL ACETATE;CHLOROMETHANOLACETATE;chloromethyl ethanoate;Acetic acid chloromethyl;3-chloropropanoate;Methanol, 1-chloro-,1-acetate
• CAS NO: 625-56-9
• Molecular Formula: C₃H₅ClO₂
• Molecular Weight: 108.52
• EINECS: 210-902-8
• Mol File: 625-56-9.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 122.85°C (rough estimate)
• Flash Point: 8.9 °C
• Appearance: /
• Density: 1.1940
• Vapor Pressure: 0.26mmHg at 25°C
• Refractive Index: 1.4090 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform, DMSO, Ethyl Acetate
• CAS DataBase Reference: Chloromethyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Chloromethyl acetate(625-56-9)
• EPA Substance Registry System: Chloromethyl acetate(625-56-9)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 625-56-9(Hazardous Substances Data)

Usage

Chemical Description

Chloromethyl acetate is a colorless liquid that is used as a reagent in organic synthesis.

Uses

Chloromethyl Acetate is a chemical reagent used in the synthesis of Ganciclovir (G235000) and related analogs. Ganciclovir is used as an anti-viral medication used primarily to combat herpes simplex virus 1.

InChI:InChI=1/C3H5ClO2/c1-2(4)3(5)6/h2H,1H3,(H,5,6)/p-1

Upstream product

• 79-20-9 acetic acid methyl ester 
• 50-00-0 formaldehyd 
• 75-36-5 acetyl chloride 
• 7782-50-5 chlorine 
• 57440-43-4 ((4-chlorophenyl)thio)methyl acetate 
• 110-88-3 1,3,5-Trioxan 
• 64-19-7 acetic acid 

Downstream Products

• 109-87-5 Dimethoxymethane 
• 79-20-9 acetic acid methyl ester 
• 607-50-1 1,1'-dinaphthylmethane 
• 930-47-2 trans-4,5-Dimethyl-1,3-dioxolan 
• 16437-69-7 (methylthio)methyl acetate 
• 628-51-3 diacetoxymethane 
• 122-79-2 Phenyl acetate 
• 6318-65-6 salicylic acid acetoxymethyl ester 
• 60-35-5 acetamide 
• 50-00-0 formaldehyd 
• 91-78-1 1,3,5-triphenylhexahydro-1,3,5-triazine 
• 137-05-3 mecrilate 
• 144-16-1 5-oxo-1,3-dioxolan-4-ylidenedi(acetic acid) 
• 2749-70-4 bis(benzyloxy)methane 

Relevant articles and documents

Methyl acetate reaction with OH and Cl: Reaction rates and products for a biodiesel analogue

Relative rate experiments performed in a photochemical reactor at 293 ± 0.5 K and a total air pressure of 980 mbar were used to determine k(CH3C(O)OCH3 + Cl) = (1.93 ± 0.27) × 10-12 cm3 molecule-1 ss

Erufosine (ErPC3) Cationic Prodrugs as Dual Gene Delivery Reagents for Combined Antitumor Therapy

Sixteen cationic prodrugs of the antitumor alkylphospholipid (APL) erufosine were rationally synthesized to provide original gene delivery reagents with improved cytotoxicity profile. The DNA complexation properties of these cationic lipids were determined and associated transfection rates were measured. Furthermore, the self-assembly properties of the pro-erufosine compounds were investigated and their critical aggregation concentration was determined. Their hydrolytic stability under pH conditions mimicking the extracellular environment and the late endosome milieu was measured. Hemolytic activity and cytotoxicity of the compounds were investigated. The results obtained in various cell lines demonstrate that the prodrugs of erufosine display antineoplastic activity similar to that of the parent antitumor drug but are not associated with hemolytic toxicity, which is a dose-limiting side effect of APLs and a major obstacle to their use in anticancer therapeutic regimen. Furthermore, by using lipoplexes prepared from a prodrug of erufosine and a plasmid DNA encoding a pro-apoptotic protein (TRAIL), evidence was provided for selective cytotoxicity towards tumor cells while nontumor cells were resistant. This study demonstrates that the combination approach involving well tolerated erufosine cationic prodrugs and cancer gene therapy holds significant promise in tumor therapy.

A class of pyrazole derivatives, preparation method and application thereof (by machine translation)

The invention discloses a following formula stru - 1 indicated by the pyrazole derivatives, The definition of each substituent in the specification. This invention relates to pyrazole derivatives suitable for use in the pest. (by machine translation)