trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(phenylmethoxy)butyl)cyclohexene

Base Information

Chemical Name:trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(phenylmethoxy)butyl)cyclohexene
CAS No.:120883-56-9
Molecular Formula:C₂₇H₄₆O₂Si
Molecular Weight:430.747
Hs Code.:

Synonyms:trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(phenylmethoxy)butyl)cyclohexene

Suppliers and Price of trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(phenylmethoxy)butyl)cyclohexene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(phenylmethoxy)butyl)cyclohexene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(phenylmethoxy)butyl)cyclohexene

There total 12 articles about trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(phenylmethoxy)butyl)cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 120883-55-8
trans-3-butyl-2-(4-(phenylmethoxy)butyl)cyclohexen-4-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 120883-56-9
trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(phenylmethoxy)butyl)cyclohexene

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;
DOI:10.1021/jo00275a023

Reference yield:

: 60789-54-0
4-bromobutyl benzyl ether

: 120883-56-9
trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(phenylmethoxy)butyl)cyclohexene

Guidance literature:: Multi-step reaction with 8 steps

2: 1.) CeCl₃*7H₂O, NaBH₄ / 1.) methanol, -78 deg C, 2.) 0 deg C, 30 min

3: 98 percent / pyridine / 12 h / Ambient temperature

4: 95 percent / triethylamine, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 24 h / Heating

5: 72 percent / LiCl, LiOAc*2H₂O, Pd(OAc)2, p-benzoquinone / acetone / 8 h

6: 89 percent / CuCN / diethyl ether / 4 h / 0 °C

7: 98 percent / 5percent aq. MeOH, K₂CO₃ / 24 h / Ambient temperature

8: 92 percent / imidazole / dimethylformamide / 3 h / 0 - 20 °C

With pyridine; 1H-imidazole; methanol; palladium diacetate; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; cerium(III) chloride; lithium acetate; potassium carbonate; triethylamine; p-benzoquinone; lithium chloride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00275a023

Reference yield:

: 120883-61-6
trans-2-butyl-3-hydroxy-1-cyclohexanone

: 120883-56-9
trans-3-butyl-4-((tert-butyldimethylsilyl)oxy)-2-(4-(phenylmethoxy)butyl)cyclohexene

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

2: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) 12 h

3: 1.) copper(I) iodide / 1.) THF, -78 deg C, 30 min, 2.) -20 deg C, 12 h

With 1H-imidazole; copper(l) iodide; lithium diisopropyl amide; In N,N-dimethyl-formamide;
DOI:10.1021/jo00275a023