(Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-1-methyl-2,5-piperazinedione

Base Information

• Chemical Name: (Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-1-methyl-2,5-piperazinedione
• CAS No.: 310903-95-8
• Molecular Formula: C₂₅H₂₉BrN₂O₅
• Molecular Weight: 517.42
• Mol file: 310903-95-8.mol

Synonyms:(Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-1-methyl-2,5-piperazinedione

Chemical Property of (Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-1-methyl-2,5-piperazinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-1-methyl-2,5-piperazinedione

There total 5 articles about (Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-1-methyl-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

(Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-2,5-piperazinedione (310903-94-7) + methyl iodide (74-88-4) → (Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-1-methyl-2,5-piperazinedione (310903-95-8)

Guidance literature:

(Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-2,5-piperazinedione; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1248/cpb.48.1549

Reference yield: 43.4%

(Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-2,5-piperazinedione (310903-94-7) + methyl iodide (74-88-4) → (Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-1,6-dimethyl-2,5-piperazinedione + (Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-1-methyl-2,5-piperazinedione (310903-95-8)

Guidance literature:

(Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-2,5-piperazinedione; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

DOI:10.1248/cpb.48.1549

Reference yield:

2-bromo-5-isopropyloxy-4-methoxy-3-methylbenzaldehyde (287117-38-8) → (Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-1-methyl-2,5-piperazinedione (310903-95-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 74.3 percent / KOtBu / 2-methyl-propan-2-ol; dimethylformamide / 1 h / 20 °C

2.1: NaH / dimethylformamide / 0.5 h / 0 °C

2.2: dimethylformamide / 42 h / 20 °C

3.1: NH₂NH₂*H₂O / dimethylformamide / 1 h / 20 °C

4.1: NaH / dimethylformamide / 0.5 h / 0 °C

4.2: 78.6 percent / dimethylformamide / 3 h / 20 °C

With potassium tert-butylate; sodium hydride; hydrazine hydrate; In N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1248/cpb.48.1549

upstream raw materials:

(Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-2,5-piperazinedione

methyl iodide

2-bromo-5-isopropyloxy-4-methoxy-3-methylbenzaldehyde

(Z)-1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-2,5-piperazinedione

Downstream raw materials:

3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

3-(5-benzyloxy-2-bromo-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione

2-(5-benzyloxy-2-bromo-4-methoxy-3-methyl-benzyl)-6-hydroxy-4-methyl-3-oxo-piperazine-1-carboxylic acid isopropyl ester

3-(3-benzyloxy-4-methoxy-5-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione