(+/-)-α-ethyl-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester

Base Information

• Chemical Name: (+/-)-α-ethyl-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester
• CAS No.: 869347-38-6
• Molecular Formula: C₂₂H₂₂N₄O₃
• Molecular Weight: 390.442
• Mol file: 869347-38-6.mol

Synonyms:(+/-)-α-ethyl-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester

Chemical Property of (+/-)-α-ethyl-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-α-ethyl-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester

There total 5 articles about (+/-)-α-ethyl-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(+/-)-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester (869347-33-1) + ethyl iodide (75-03-6) → (+/-)-α-ethyl-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester (869347-38-6)

Guidance literature:

(+/-)-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h;

ethyl iodide; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm050257d

Reference yield:

3-azidophenylacetic acid ethyl ester (869347-25-1) → (+/-)-α-ethyl-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester (869347-38-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 74 percent / N-bromosuccinimide; AIBN / CCl₄ / 5 h / Heating

2.1: NaH / tetrahydrofuran / 1 h / 20 °C

2.2: 65 percent / tetrahydrofuran / 15 h / Heating

3.1: lithium diisopropylamide / tetrahydrofuran / 2 h / -78 °C

3.2: 80 percent / tetrahydrofuran / 2 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane;

DOI:10.1021/jm050257d

Reference yield:

(+/-)-α-bromo-(3-azidophenyl)acetic acid ethyl ester (869347-28-4) → (+/-)-α-ethyl-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester (869347-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 20 °C

1.2: 65 percent / tetrahydrofuran / 15 h / Heating

2.1: lithium diisopropylamide / tetrahydrofuran / 2 h / -78 °C

2.2: 80 percent / tetrahydrofuran / 2 h / Heating

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/jm050257d

upstream raw materials:

(+/-)-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester

ethyl iodide

3-azidophenylacetic acid ethyl ester

(+/-)-α-bromo-(3-azidophenyl)acetic acid ethyl ester

Downstream raw materials:

5-(3-azido-phenyl)-5-ethyl-6-oxa-10b-aza-benzo[e]azulen-4-one

(+/-)-α-ethyl-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid