benzyl 4-(N-cyano-S-methylsulfinimidoyl)-2-{[(benzyloxy)carbonyl]amino}butanoate

Base Information

• Chemical Name: benzyl 4-(N-cyano-S-methylsulfinimidoyl)-2-{[(benzyloxy)carbonyl]amino}butanoate
• CAS No.: 1616972-83-8
• Molecular Formula: C₂₁H₂₃N₃O₄S
• Molecular Weight: 413.497
• Mol file: 1616972-83-8.mol

Synonyms:benzyl 4-(N-cyano-S-methylsulfinimidoyl)-2-{[(benzyloxy)carbonyl]amino}butanoate

Chemical Property of benzyl 4-(N-cyano-S-methylsulfinimidoyl)-2-{[(benzyloxy)carbonyl]amino}butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-(N-cyano-S-methylsulfinimidoyl)-2-{[(benzyloxy)carbonyl]amino}butanoate

There total 3 articles about benzyl 4-(N-cyano-S-methylsulfinimidoyl)-2-{[(benzyloxy)carbonyl]amino}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

CYANAMID (420-04-2) + benzyl 2-{[(benzyloxy)carbonyl]amino}-4-(methylthio)butanoate (126401-21-6) → benzyl 4-(N-cyano-S-methylsulfinimidoyl)-2-{[(benzyloxy)carbonyl]amino}butanoate (1616972-83-8)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In acetonitrile; at 0 - 20 ℃;

DOI:10.1002/adsc.201400354

Reference yield:

N-(benzyloxycarbonyl)methionine (4434-61-1) → benzyl 4-(N-cyano-S-methylsulfinimidoyl)-2-{[(benzyloxy)carbonyl]amino}butanoate (1616972-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-cyclohexyl-cyclohexanamine / dichloromethane; N,N-dimethyl-formamide / 24 h

2: [bis(acetoxy)iodo]benzene / acetonitrile / 0 - 20 °C

With [bis(acetoxy)iodo]benzene; N-cyclohexyl-cyclohexanamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/adsc.201400354

Reference yield:

benzyl bromide (100-39-0) → benzyl 4-(N-cyano-S-methylsulfinimidoyl)-2-{[(benzyloxy)carbonyl]amino}butanoate (1616972-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-cyclohexyl-cyclohexanamine / dichloromethane; N,N-dimethyl-formamide / 24 h

2: [bis(acetoxy)iodo]benzene / acetonitrile / 0 - 20 °C

With [bis(acetoxy)iodo]benzene; N-cyclohexyl-cyclohexanamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/adsc.201400354

upstream raw materials:

N-(benzyloxycarbonyl)methionine

CYANAMID

benzyl 2-{[(benzyloxy)carbonyl]amino}-4-(methylthio)butanoate

benzyl bromide

Downstream raw materials:

benzyl 4-(N-cyano-S-methylsulfonimidoyl)-2-{[(benzyloxy)carbonyl]amino}butanoate