1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Base Information

Chemical Name:1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine
CAS No.:1439397-25-7
Molecular Formula:C₂₃H₂₂N₄
Molecular Weight:354.454
Hs Code.:

Synonyms:1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

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Chemical Property of 1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

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Technology Process of 1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

There total 6 articles about 1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439397-29-1
{1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

: 1439397-25-7
1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 13162-26-0
2,4-dichloro-6-methyl-5-nitropyrimidine

: 1439397-25-7
1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium on activated charcoal; potassium acetate; hydrogen / methanol / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere

2.2: 1.5 h / -78 - 20 °C / Inert atmosphere

3.1: potassium hydroxide / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3.2: 0.25 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / Inert atmosphere; Cooling with ice

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; acetonitrile / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

6.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; palladium on activated charcoal; hydrogen; potassium acetate; potassium carbonate; caesium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1439397-27-9
7-iodo-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine

: 1439397-25-7
1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutylamine

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; acetonitrile / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

2: hydrogenchloride / ethyl acetate / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; ethyl acetate; acetonitrile;