{1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester
CAS No.:1439397-29-1
Molecular Formula:C₂₈H₃₀N₄O₂
Molecular Weight:454.572
Hs Code.:

Synonyms:{1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

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Chemical Property of {1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

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Technology Process of {1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

There total 5 articles about {1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1439397-27-9
7-iodo-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine

: 1439397-29-1
{1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; acetonitrile; at 100 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 13162-26-0
2,4-dichloro-6-methyl-5-nitropyrimidine

: 1439397-29-1
{1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium on activated charcoal; potassium acetate; hydrogen / methanol / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere

2.2: 1.5 h / -78 - 20 °C / Inert atmosphere

3.1: potassium hydroxide / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3.2: 0.25 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / Inert atmosphere; Cooling with ice

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; acetonitrile / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; palladium on activated charcoal; hydrogen; potassium acetate; potassium carbonate; caesium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1439397-21-3
7-iodo-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine

: 1439397-29-1
{1-[4-(5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / Inert atmosphere; Cooling with ice

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; acetonitrile / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; caesium carbonate; In water; N,N-dimethyl-formamide; acetonitrile;