[4-(2-tert-butoxycarbonylamino-ethoxy)-2-nitro-phenoxy]-acetic acid methyl ester

Base Information

• Chemical Name: [4-(2-tert-butoxycarbonylamino-ethoxy)-2-nitro-phenoxy]-acetic acid methyl ester
• CAS No.: 845887-33-4
• Molecular Formula: C₁₆H₂₂N₂O₈
• Molecular Weight: 370.359
• Mol file: 845887-33-4.mol

Synonyms:[4-(2-tert-butoxycarbonylamino-ethoxy)-2-nitro-phenoxy]-acetic acid methyl ester

Chemical Property of [4-(2-tert-butoxycarbonylamino-ethoxy)-2-nitro-phenoxy]-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [4-(2-tert-butoxycarbonylamino-ethoxy)-2-nitro-phenoxy]-acetic acid methyl ester

There total 3 articles about [4-(2-tert-butoxycarbonylamino-ethoxy)-2-nitro-phenoxy]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(N-tert-butoxycarbonylamino)ethanol (26690-80-2) + methyl [(4-hydroxy-2-nitrophenyl)oxy]acetate (583031-18-9) → [4-(2-tert-butoxycarbonylamino-ethoxy)-2-nitro-phenoxy]-acetic acid methyl ester (845887-33-4)

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; at 20 ℃; for 6h;

DOI:10.1016/j.bmcl.2004.11.030

Reference yield:

4-hydroxy-3-nitrophenyl benzoate (13985-43-8) → [4-(2-tert-butoxycarbonylamino-ethoxy)-2-nitro-phenoxy]-acetic acid methyl ester (845887-33-4)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / acetone / 18 h / Heating

2: NaOMe / methanol / 1 h / 20 °C

3: 85 percent / Bu₃P; 1,1'-(azodicarbonyl)dipiperidine / 6 h / 20 °C

With tributylphosphine; sodium methylate; potassium carbonate; 1,1'-azodicarbonyl-dipiperidine; In methanol; acetone; 3: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2004.11.030

Reference yield:

benzoic acid 4-methoxycarbonylmethoxy-3-nitrophenyl ester (583031-17-8) → [4-(2-tert-butoxycarbonylamino-ethoxy)-2-nitro-phenoxy]-acetic acid methyl ester (845887-33-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOMe / methanol / 1 h / 20 °C

2: 85 percent / Bu₃P; 1,1'-(azodicarbonyl)dipiperidine / 6 h / 20 °C

With tributylphosphine; sodium methylate; 1,1'-azodicarbonyl-dipiperidine; In methanol; 2: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2004.11.030

upstream raw materials:

2-(N-tert-butoxycarbonylamino)ethanol

methyl [(4-hydroxy-2-nitrophenyl)oxy]acetate

4-hydroxy-3-nitrophenyl benzoate

benzoic acid 4-methoxycarbonylmethoxy-3-nitrophenyl ester