(2R)-2-methyl-2-pyrrolidinecarboxamide

Base Information

Chemical Name:(2R)-2-methyl-2-pyrrolidinecarboxamide
CAS No.:132235-42-8
Molecular Formula:C₆H₁₂N₂O
Molecular Weight:128.174
Hs Code.:

Synonyms:(2R)-2-methyl-2-pyrrolidinecarboxamide

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Chemical Property of (2R)-2-methyl-2-pyrrolidinecarboxamide

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Technology Process of (2R)-2-methyl-2-pyrrolidinecarboxamide

There total 14 articles about (2R)-2-methyl-2-pyrrolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1361112-89-1
2-methylpyrrolidine-2-carboxamide hydrochloride

: 132235-42-8
(2R)-2-methyl-2-pyrrolidinecarboxamide

: 42856-71-3
(S)-2-methylpyrrolidine-2-carboxylic acid

Guidance literature:: With peptidase R; water; sodium hydroxide; at 40 ℃; for 162h; pH=7; Time; Enzymatic reaction;

Reference yield: 51.0%

: 848488-83-5
DL-(α-methyl)proline amide

: 132235-43-9
(S)-2-methylpyrrolidine-2-carboxylic acid amide

: 132235-42-8
(2R)-2-methyl-2-pyrrolidinecarboxamide

: 63399-77-9
(R)-2-Methyl-1-azacyclopentan-2-carbonsaeure

Guidance literature:: With Mycobacterium neoaurum ATCC 25795 amidase; acetic acid; In water; at 37 ℃; for 70h; pH=8.5; optical yield given as %ee; stereoselective reaction; Resolution of racemate; Enzymatic reaction;
DOI:10.1002/chem.200900688

Reference yield:

: 5891-21-4
5-chloro-2-pentanone

: 132235-42-8
(2R)-2-methyl-2-pyrrolidinecarboxamide

: 42856-71-3
(S)-2-methylpyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate / water; tert-butyl alcohol / 2.5 h / 50 °C

1.2: 2.5 h

1.3: 24 h / 15 - 20 °C

2.1: hydrogenchloride / water

3.1: sodium hydroxide; peptidase R; water / 162 h / 40 °C / pH 7 / Enzymatic reaction

With hydrogenchloride; peptidase R; ammonium acetate; water; sodium hydroxide; In water; tert-butyl alcohol;