phenyl 3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperdine-1-yl)propoxy)quinolin-4-yloxy)phenylcarbamate

Base Information

Chemical Name:phenyl 3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperdine-1-yl)propoxy)quinolin-4-yloxy)phenylcarbamate
CAS No.:1449763-32-9
Molecular Formula:C₃₂H₃₄FN₃O₅
Molecular Weight:559.637
Hs Code.:

Synonyms:phenyl 3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperdine-1-yl)propoxy)quinolin-4-yloxy)phenylcarbamate

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Chemical Property of phenyl 3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperdine-1-yl)propoxy)quinolin-4-yloxy)phenylcarbamate

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Technology Process of phenyl 3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperdine-1-yl)propoxy)quinolin-4-yloxy)phenylcarbamate

There total 10 articles about phenyl 3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperdine-1-yl)propoxy)quinolin-4-yloxy)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.3%

: 1290538-61-2
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

: 1449763-32-9
phenyl 3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperdine-1-yl)propoxy)quinolin-4-yloxy)phenylcarbamate

Guidance literature:: With potassium carbonate; In acetone; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmc.2013.06.026

Reference yield: 82.3%

: 1290538-61-2
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

: 1885-14-9
phenyl chloroformate

: 1449763-32-9
phenyl 3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperdine-1-yl)propoxy)quinolin-4-yloxy)phenylcarbamate

Guidance literature:: With potassium carbonate; In acetone; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmc.2016.02.003

Reference yield:

: 1160707-44-7
1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

: 1449763-32-9
phenyl 3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperdine-1-yl)propoxy)quinolin-4-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: toluene / 110 °C

2: iron / acetic acid / 2 h / 40 - 80 °C

3: acetonitrile / 8 h / 25 - 80 °C

4: trichlorophosphate / acetonitrile / Reflux

5: chlorobenzene / 20 h / 140 °C

6: iron; hydrogenchloride / ethanol; water / 2 h / Reflux

7: potassium carbonate / acetone / 3 h / 0 - 20 °C

With hydrogenchloride; iron; potassium carbonate; trichlorophosphate; In ethanol; water; acetic acid; chlorobenzene; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.06.026